Jeremiah Black is unwittingly trapped in Hell after heroically saving his family from a serial killer one fateful night during the 1890's. There he finds himself propositioned by none other than the Devil himself. Resurrected and immortal, he is forced to kill his wife and entire bloodline over the course of the next century in order to appease the Devil. When two Inspectors attempt to halt his killing spree, he murders them, or so he thinks. One of them, Inspector Jackson Granger, through a freak mishap of Black's blood mixing with his own while wounded finds himself immortal. Looking to end Black's reign of terror, and bent on getting revenge for his murdered partner, Jackson sets out to find Black, and destroy him even if he has to battle against the power of the Devil himself.