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Introduction to Proteins: Structure, Function, and Motion, Second Edition de Amit Kessel

Introduction to Proteins: Structure, Function, and Motion, Second Edition: Chapman & Hall/CRC Computational Biology Series

Autor Amit Kessel, Nir Ben-Tal
en Limba Engleză Hardback – 11 apr 2018

Relevanța acestei lucrări pentru examenele de biofizică și biochimie, precum și pentru certificările în biologia structurală, este incontestabilă, oferind un suport academic riguros pentru studenții de nivel avansat. În această a doua ediție a Introduction to Proteins, Amit Kessel și Nir Ben-Tal extind analiza structurii și funcției proteinelor, integrând dimensiunea crucială a mișcării și dinamicii moleculare. Observăm o tranziție de la modelul static al proteinelor către o înțelegere fluidă, esențială în contextul cercetării moderne.

Structura volumului este progresivă, pornind de la fundamentele structurii și stabilității energetice, trecând prin metode de determinare experimentală și culminând cu secțiuni complexe despre proteinele membranare și interacțiunile ligand-proteină. Un element distinctiv al acestei ediții este capitolul dedicat catalizei enzimatice, care nu doar explică termodinamica și cinetica, ci utilizează tehnologia QR pentru a oferi animații ale reacțiilor biochimice. Putem afirma că această abordare hibridă, care combină textul academic cu resursele digitale, facilitează înțelegerea proceselor moleculare invizibile.

Comparativ cu Proteins de Paulo Almeida, care se concentrează pe logica principiilor biofizice într-un format de un semestru, lucrarea de față este mult mai cuprinzătoare, având aproape 1000 de pagini și o orientare pronunțată către aplicații medicale și design de medicamente. Reprezintă o alternativă robustă la Protein Structure and Function pentru cursurile de biofizică, cu avantajul includerii proteinelor intrinsec nestructurate, oferind o imagine realistă asupra proteomului care depășește dogma clasică structură-funcție.

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Specificații

ISBN-13: 9781498747172
ISBN-10: 1498747175
Pagini: 988
Ilustrații: 32 Tables, black and white; 300 Illustrations, color
Dimensiuni: 210 x 280 x 52 mm
Greutate: 2.9 kg
Ediția:2. Auflage
Editura: CRC Press
Colecția Chapman and Hall/CRC
Seria Chapman & Hall/CRC Computational Biology Series

Locul publicării:Boca Raton, United States

De ce să citești această carte

Această carte este o resursă fundamentală pentru studenții și cercetătorii care doresc să stăpânească biologia structurală. Cititorul câștigă o înțelegere profundă a modului în care dinamica proteinelor influențează sănătatea și boala. Este recomandată celor care se pregătesc pentru cariere în farmacologie sau bioinginerie, oferind atât baza teoretică, cât și instrumentele computaționale necesare pentru modelarea interacțiunilor moleculare complexe.

Despre autor

Amit Kessel și Nir Ben-Tal sunt cercetători recunoscuți în domeniul biologiei computaționale, cu o expertiză vastă în modelarea structurii proteinelor. Nir Ben-Tal este profesor la Universitatea din Tel Aviv, unde conduce un laborator axat pe studiul funcției proteinelor prin metode bioinformatice și biofizice. Colaborarea lor pentru acest volum din seria Chapman & Hall/CRC Computational Biology Series reflectă o sinteză între rigoarea matematică și aplicațiile biologice practice. Experiența lor didactică este evidentă în structura pedagogică a cărții, care include exerciții și rezumate menite să faciliteze asimilarea conceptelor dificile de către studenți.

Cuprins

Introduction. Protein Structure. Methods of Structure Determination and Prediction. Energetics and Protein Stability. Protein Dynamics. Intrinsically Unstructured Proteins. Membrane-Bound Proteins. Protein-Ligand Interactions. Enzymatic Catalysis

Recenzii

"This is the most interesting to read and complete text I have found for senior undergraduate or early graduate-level coverage of protein structure and function, and a great reference book to have on hand. This text is significantly updated and printed in a hardcover format with easy-to-read text (larger font and pages than usual, with margins for note-taking) and comes with annotatable ebook access for free. Overall, this is a significantly enriched 2nd edition of a book we have used successfully for several years now, which I enthusiastically recommend!" --Leslie Kuhn, Departments of Biochemistry & Molecular Biology and Computer Science & Engineering, Michigan State University, USA
"I used this book when studying for a course on the Mechanisms of Enzyme Catalysis. The book made everything I was struggling with so clear! It is extremely well organized and very, very thorough which makes studying from it easy! 10/10 would recommend to anyone studying proteins and/or enzymes, or even someone who just wants to learn more. Anyone looking for a supplementary reading for your course should have this text book - even if you think you don't need it, trust me, you do." --Customer review on Amazon.com
Praise for the First edition:
"This book offers a unique combination of structure, thermodynamics and biology. I was impressed both by the breadth of the topics covered and by the depth in which they are treated. General principles are made intuitively clear based on well-chosen examples, many of them having relevance to disease. The book could fit well as a textbook in structural biology and molecular biophysics courses." --Barry Honig, Columbia University, New York, New York, USA
"I’ve just lately used this textbook for a presentation on electrostatics. Although I have an organic background, I discovered that the explanations of electrostatic interactions are very clear and informative. The language isn’t too technical and may be easily understood by biology students. The textbook covers numerous examples and colorful illustrations, which made it easy to understand the principles discussed. The book is well organized in chapters for all the fundamental topics. I feel this book would be appropriate for any undergraduate and graduate scholar who’s keen on proteins. … It’s complete, easy to observe and (something I at least discover uncommon for textbooks) pleasing to read. The authors don’t shrink back from any subjects, but clarify things in a straightforward method supported by ample examples. Highly recommended." --Physics Book Reviews at dowdawgs.com, May 2013
"Introduction to Proteins is an excellent, state-of-the-art choice for students, faculty, or researchers needing a monograph on protein structure. …The book is clear, well organized, aptly illustrated in color, and a pleasure to read. The first two chapters are an impressive textbook unto themselves … The book is thoroughly documented with citations to the literature gathered at the end of each chapter. … Overall, this is an immensely informative, thoroughly researched, up-to-date text, with broad coverage and remarkable depth. Introduction to Proteins would provide an excellent basis for an upper level or graduate course on protein structure, and a valuable addition to the libraries of professionals interested in this centrally important field." --Eric Martz, Biochemistry and Molecular Biology Education, Vol. 40, 2012
"This is an important book. It captures in a very accessible way a growing body of literature on the structure, function and motion of proteins, and links this to more established paradigms such as a reader might find in a mainstream biochemistry text. The text is littered with excellent examples of the wider relevance of the material covered. The book is also exceptionally well written. I learned new things from each chapter. Overall, a superb publication that would be very useful to undergraduates, graduate students, postdoctoral researchers and instructors involved in structural biology or biophysics courses or in research on protein structure–function relationships. I would recommend it highly." --David Sheehan, ChemBioChem, 2011
"The book provides general guidelines for understanding protein structure and demonstrates how we can use the structure to phrase testable hypotheses about biological function. The repeated use of the same example makes it easier for the reader to grasp the general principles. The book gives a coherent picture of each topic and includes ample references, making it possible for the interested reader to dig deeply into various topics. The book also covers structural aspects of intrinsically unstructured proteins and how this property facilitates their biological function. It provides background in cell biology, basic chemistry and thermodynamics, making it useful for newcomers to the protein structure field who want to catch up quickly. It is also easy for experts to dive into the more specialized aspects quickly. The book provides references to user-friendly web tools in the field. The publisher’s website provides exercises on both theory and practice. Sample solutions and PowerPoint presentations are available for qualified teachers. These make the book attractive as the main textbook in an undergraduate course on protein structure, for parts of freshman biochemistry, and as a supplement for many undergraduate and graduate courses." --Burkhard Rost, Technische Universität München, Germany

Notă biografică

Dr. Amit Kessel co-founded and headed the R&D department of ES-IS Technologies, which designs novel enzymatic solutions for the pharmaceutical industry. He studied and trained at Tel-Aviv University and Columbia University, and is currently involved in several academic and industrial biotech initiatives, focusing on experimentally-guided protein structure prediction and on the in-vitro construction of protein-based nanoparticles.
Professor Nir Ben-Tal is based in the Department of Biochemistry and Molecular Biology at Tel Aviv University. His lab has predicted the 3-D structures of numerous transmembrane proteins, providing molecular insight into their mechanisms, and has also developed the ConSurf web-server for the detection of functional regions by mapping evolutionary data onto protein structures (jointly with the Mayrose and Pupko labs). He studied and trained at the Hebrew University, the Technion, Israel Institute of Technology, and Columbia University.

Descriere scurtă

Introduction to Proteins provides a comprehensive and state-of-the-art introduction to the structure, function, and motion of proteins for students, faculty, and researchers at all levels. The book covers proteins and enzymes across a wide range of contexts and applications, including medical disorders, drugs, toxins, chemical warfare, and animal behavior. Each chapter includes a Summary, Exercises, and References.
New features in the thoroughly-updated second edition include:
  • A brand-new chapter on enzymatic catalysis, describing enzyme biochemistry, classification, kinetics, thermodynamics, mechanisms, and applications in medicine and other industries. These are accompanied by multiple animations of biochemical reactions and mechanisms, accessible via embedded QR codes (which can be viewed by smartphones)
  • An in-depth discussion of G-protein-coupled receptors (GPCRs)
  • A wider-scale description of biochemical and biophysical methods for studying proteins, including fully accessible internet-based resources, such as databases and algorithms
  • Animations of protein dynamics and conformational changes
Additional features
  • Extensive discussion of the energetics of protein folding, stability and interactions
  • A comprehensive view of membrane proteins, with emphasis on structure-function relationship
  • Coverage of intrinsically unstructured proteins, providing a complete, realistic view of the proteome and its underlying functions
  • Exploration of industrial applications of protein engineering and rational drug design
  • Each chapter includes a Summary, Exercies, and References
  • Approximately 300 color images
  • Downloadable solutions manual available at www.crcpress.com
For more information, including all presentations, tables, animations, and exercises, as well as a complete teaching course on proteins' structure and function, please visit the author's website: https://bentalab.sites.tau.ac.il/protein-book.
Praise for the first edition
"This book captures, in a very accessible way, a growing body of literature on the structure, function and motion of proteins. This is a superb publication that would be very useful to undergraduates, graduate students, postdoctoral researchers, and instructors involved in structural biology or biophysics courses or in research on protein structure-function relationships." --David Sheehan, ChemBioChem, 2011
"Introduction to Proteins is an excellent, state-of-the-art choice for students, faculty, or researchers needing a monograph on protein structure. This is an immensely informative, thoroughly researched, up-to-date text, with broad coverage and remarkable depth. Introduction to Proteins would provide an excellent basis for an upper-level or graduate course on protein structure, and a valuable addition to the libraries of professionals interested in this centrally important field." --Eric Martz, Biochemistry and Molecular Biology Education, 2012

Descriere

Introduction to Proteins shows how proteins can be analyzed in multiple ways. It refers to the roles of proteins and enzymes in diverse contexts and everyday applications, including medical disorders, drugs, toxins, chemical warfare, and animal behavior.