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Insulin - The Crooked Timber: A History from Thick Brown Muck to Wall Street Gold

Autor Kersten T. Hall
en Limba Engleză Hardback – 20 ian 2022
Before the discovery of insulin, a diagnosis of Type 1 diabetes was a death sentence. One hundred years after a milestone medical discovery, 'Insulin - The Crooked Timber' tells the story of how insulin was transformed from what one clinician called 'thick brown muck' into the very first drug to be produced using genetic engineering, one which would earn the founders of the US biotech company Genentech a small fortune.Yet when Canadian doctor Frederick Banting was told in 1923 that he had won the Nobel Prize for this life-saving discovery, he was furious. For the prize had not been awarded to him alone - but jointly with a man whom he felt had no right to this honour. The human story behind this discovery is one of ongoing political and scientific controversy.Taking the reader on a fascinating journey, starting with the discovery of insulin in the 1920s through to the present day, 'Insulin - The Crooked Timber' reveals a story of monstrous egos, toxic career rivalries, and a few unsung heroes such as two little known scientists whose work on wool fibres, carried out in a fume-filled former stable, not only proved to be crucial in unravelling the puzzle of insulin but ushered in a revolution in biology.It was the author's own shocking diagnosis with Type 1 diabetes that prompted him to sit down and write this book, but this story has lessons for us all about what technology can - and more importantly cannot - do for us. As the world pins its hopes on effective and lasting vaccines against Covid-19, these lessons from the story of insulin have never been more relevant.
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Specificații

ISBN-13: 9780192855381
ISBN-10: 0192855387
Pagini: 480
Ilustrații: 71 line diagrams and halftones
Dimensiuni: 163 x 240 x 28 mm
Greutate: 0.95 kg
Editura: OUP OXFORD
Colecția OUP Oxford
Locul publicării:Oxford, United Kingdom

Recenzii

[uses] a blend of profound research, lively writing and personal knowledge of diabetes
The lengthy bibliography and endnotes are a testament to the extensive research that has been carried out to produce this fascinating account.
The story of insulin over the past 100 years, as the historian of science (and former molecular biologist) Kersten Hall shows in this dense and fascinating book, is also a microcosm of developments in science more widely, and of changes in the politics and economics of healthcare.[...] The pleasures of this book lie mainly in the storytelling detail and the gossipy richness of the lives, friendships and feuds glimpsed in the hubbub of decades pursuing the improvement of human health.
... comprehensive account of the modern medical history of the hormone...
A fascinating book by an author with excellent credentials, well written and meticulously researched.
A timely book, pulling together many interesting stories about the scientific side of insulin.
Reviews the events around the discovery of insulin in an original and well-documented manner.
Written in a clear and engaging style, the book provides a fresh take on historic events and also delves into aspects that have not been adequately explored previously.
It is a good read and scholarly account.
Insulin-the Crooked Timber is essential reading for anyone concerned with the history of insulin.
Hall's The Crooked Timber expertly combines careful attention to the science with thoughtful consideration of its historical and philosophical dimensions.
I expected it to be interesting - or at least the part dealing with Dick [my father] and Archer's work. What I didn't expect was that it would be a 'page turner' from start to finish!

Notă biografică

Kersten Hall graduated with an honours degree in biochemistry from St. Anne's College, University of Oxford, and completed a PhD in gene regulation in adenoviruses before working for the School of Medicine at the University of Leeds. He then hung up his lab coat and began to write about science. His book 'The Man in the Monkeynut Coat' (OUP 2014) tells the story of pioneering physicist William Astbury whose research into wool fibres led him to make the very first studies of the structure of DNA. The book was shortlisted for the 2015 British Society for the History of Science Dingle Prize and was featured on a list of 'Books of 2014' in The Guardian. He is currently a visiting fellow in the School of Philosophy, Religion and History of Science at the University of Leeds where his research concerns the history of molecular biology but after a shocking diagnosis with Type 1 diabetes ten years ago he turned to the story of insulin.

Cuprins

  • Preface
  • Looking a Gift Horse in the Mouth?
  • Introduction
  • Taming the Tiger
  • 1: The Pissing Evil - a colourful description of diabetes by 17th century English physician Thomas Willis
  • 2: Thick Brown Muck - Canadian scientist Fred Banting wins the Nobel Prize for the discovery of insulin... and is furious
  • 3: The Vision of Ezekiel - clinicians are stunned at the power of insulin to save lives, but it proves to be a double-edged sword
  • 4: A Greek Tragedy - German clinician Georg Zuelzer snatches defeat from the jaws of victory
  • 5: The Wasp's Nest - insulin proves to be a poisoned chalice for its discoverers
  • 6: Be Careful What You Wish For - the case of Romanian scientist Nicolai Paulesco underlines the truth of an old proverb
  • 7: 'In Praise of Wool' - the humble wool fibre sets in motion a revolution in biochemistry
  • 8: A Boastful Undertaking - a discovery made in a fume-filled stable offers the key to unlocking insulin
  • 9: The Blobs That Won a Nobel Prize - or two, all thanks to some coloured spots on a piece of filter paper
  • 10: The Prophet in the Labyrinth - biochemist Erwin Chargaff helps unlock the secrets of DNA, but fears where this may lead
  • 11: The Clone Wars - a conflict in which insulin proves to be a decisive weapon
  • 12: Wall Street Gold - in an act of modern day alchemy, insulin makes stock market history
  • 13: 'Don't You Want Cheap Insulin?' - What is it exactly that we want from science? And does the story of insulin have any lessons for us today?
  • Bibliography
  • Figures List and Acknowledgements for Images
  • Acknowledgements
  • End notes