Welcome to the instructor's guide for the second edition of High Reliability Organizations: A Healthcare Handbook for Patient Safety & Quality. This guide is designed to be a resource for educators in a variety of academic settings in courses focused on patient safety or quality management in nursing, health services administration, or clinical programs. This instructor's guide is divided into three sections: Unit 1: Using the Textbook for Teaching and Learning Unit 2: Resources for Teaching High Reliability for Patient Safety and Quality Unit 3: Chapter Learning Activities and Instructor Support This guide provides suggestions to guide faculty, nurse leaders, clinical staff nurses, quality and safety staff, or other healthcare professionals who are teaching others about the application of HRO principles to patient safety and quality problems using the second edition of High Reliability Organizations: A Healthcare Handbook for Patient Safety & Quality. For academic faculty, the chapter-by-chapter learning activities will help facilitate student learning about application of high reliability to patient safety and quality and can be used as part of a patient safety and quality course at a variety of academic levels. The student workbook contains the same chapter-by-chapter learning activities found in the instructor's guide. The instructor's guide contains supplemental materials including learning activity implementation strategies and student evaluation sections. There are several completed examples of fill-in responses or answers for instructors as well. A summative learning activity is included that gives instructors the opportunity to assess student ability to translate high reliability principles into practice.