I Ching created from keen observation of the nature in the universe. The key components of Yi Jing are the yin and yang duality, the four phenomena, trigram, two sets of eight trigrams, the 64 hexagrams, two sets of 64 trigrams. The yin and yang duality of the universe posited in Yi Jing correlates with the matter duality of the universe theorized in quantum mechanics. The four phenomena are two sets of four yin and yang configurations. They correlate with DNA and RNA four chemicals configuration. Trigram is the triple yin and yang configuration, it correlates with codon which is the three-chemical configuration in DNA and RNA. The two sets of 64 trigrams in Yi Jing correlate with the two sets of 64 codons in DNA and RNA. Yi Jing's hexagrams and lines are the external factors of changes that offer seekers accurate advice for dilemmatic issues in oracle use.