The bedrock scientific facts supporting HBOT are in this companion book relating to its clinical application. Hyperbaric oxygen therapy (HBOT) has been used to varying degrees of effectiveness to treat a wide spectrum of diseases but HBOT has not established itself as a mainstay in overall medical practice. However, I find it exciting that another prooxidant therapy has established itself in the general field of medical science. As with all medical science topics, experiments range from low quality to those that are conducted carefully for wound healing, wounds in diabetics, radiation tissue injury, multiple sclerosis, autism, Crohn's disease, cancer, Alzheimer's disease, etc. One has to try to assimilate the data and arrive at a reasonable substantiated conclusion as regards the risk/benefit ratio for HBOT. Overall, I have found sound biochemical rationale for the use of HBOT in pathogen protection, increased wound healing and cancer prevention and potential cure. Of particular interest to me, is the fact that electronically modified oxygen derivatives (EMODs, formerly incorrectly called reactive oxygen species, ROS) are front and center in the biochemical mechanisms involving HBOT. This dove tails with other treatment modalities such as phototherapy, photodynamic therapy (PDT), sonodynamic therapy, the Howes tumoricidal system, chemotherapy and radiation therapy. EMOD involvement also has a commonality with the benefits seen with exercise and in the high oxidative stress metabolism seen in the naked mole rat. No doubt, EMOD-induced apoptosis (cellular suicide) is a key factor in holding cancer at bay and in killing cancerous cells. I have arduously summarized the studies and provided a condensed listing of the conditions that have been successfully treated with HBOT. Is there a commonality between the effects of HBOT, the increased healthspan and increased lifespan of the naked mole rat and the effects of increased oxygen consumption associated with exercise? What are the diseases that have been successfully treated with HBOT? Can HBOT prevent or stop cancerous cells from growing or metastasizing? Will HBOT become accepted in the mainstream practice of medicine? Dr. Howes was the first in the history of Tulane School of Medicine to receive double doctorate degrees in medicine and biochemistry simultaneously and he invented the triple lumen venous catheter, which has been credited with helping save the lives of over 20 million critically ill patients worldwide. Dr. Howes forthrightly tackles the controversial subject of hyperbaric oxygen therapy in this unique and exciting book.