This volume contains the proceedings of the Sixth Workshop on Hybrid Systems: Computation and Control (HSCC 2003), which was held in Prague, during April 3–5, 2003. The Hybrid Systems workshops attract researchers interested in the modeling, analysis, control, and implementation of systems which involve the interaction of both discrete and continuous state dynamics. The newest results and latest developments in hybrid system models, formal methods for analysis and control, computational tools, as well as new applications and examples are presented at these annual meetings. The Sixth Workshop continued the series of workshops held in Grenoble, France (HART’97), Berkeley, California, USA (HSCC’98), Nijmegen, The Neth- lands (HSCC’99), Pittsburgh, Pennsylvania, USA (HSCC 2000), Rome, Italy (HSCC 2001), and Stanford, California, USA (HSCC 2002). Proceedings of these workshops have been published by Springer-Verlag in the Lecture Notes in C- puter Science (LNCS) series. This year we assembled a technical program committee with a broad expertise in formal methods in computer science, control theory, applied mathematics, and arti?cial intelligence. We received a set of 75 high-quality submitted papers. After detailed review and discussion of these papers by the program committee, 36 papers were accepted for presentation at the workshop, and the ?nal versions of these papers appear in this volume.