The COVID-19 pandemic has dramatically affected education at all levels and classrooms have been forced to turn to distance teaching. In response, society has adapted to a new means of communication, leading to a lasting transformation in how we teach, learn, and work—often through hybrid models that blend in-person and online engagement. This book explores such unique educational scenarios from both theoretical and practical perspectives, offering conceptual frameworks, design guidelines and experience-based examples. It presents strategies for educators to effectively design and facilitate hybrid learning activities, while also empowering students to engage meaningfully in these environments. The authors propose scientifically grounded pedagogical approaches that promote active learning, support teacher-student and peer-to-peer interaction, and encourage learner self-regulation. The main goals of the book are: • To clarify the definition of hybrid teaching and learning • To detail some of the main conceptual pillars of hybrid teaching and learning • To describe some of the most relevant of hybrid teaching and learning modes • To discuss and clarify important operational guidelines to support hybrid teaching and learning • To provide practical application cases of hybrid teaching and learning modes