A year after the mysterious death of his wife, Professor Derek Flynn finds himself waking up, as if from a blackout, in the middle of a catastrophic and fatal disaster. Derek has no idea how he got there, but what's even more inexplicable is that this has become a common occurrence. In fact, Derek has been lying to his estranged teenage daughter, Casey, about his puzzling disappearances for months. Desperate to get to the bottom of what's happening to him, Derek reaches out to psychologist Alice Meyers seeking help to recognize the terrifying visions that haunt his dreams: imminent disasters, both natural and manmade, that Derek now feels he is somehow integral to. But with the FBI catching on to his connection with these disastrous events, a manhunt begins, and Derek finds himself tangled in a perplexing web.

Stuck between being a fugitive and a messiah, and on the run in his pursuit for the truth, Derek will discover that there are no such things as coincidences.