A great deal has been accomplished in the 5 years following the release of Healthy People 2000: National Health Promotion and Disease Prevention Objectives. Americans are living longer; infant mortality is at a record low level; childhood immunizations are increasing; tobacco use is declining; and more women over age 50 are receiving mammograms at recommended intervals. The Healthy People 2000 Midcourse Review and 1995 Revisions--the mid-decade report on the Nation's prevention agenda--provides us with the good news. This publication also shows that many challenges remain in preventing premature death and in improving health as the next century approaches.