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Handbook of Mitochondrial Dysfunction

Editat de Shamim I. Ahmad
en Limba Engleză Paperback – 30 sep 2021
Mitochondria produce the chemical energy necessary for eukaryotic cell functions; hence mitochondria are an essential component of health, playing roles in both disease and aging. More than 80 human diseases and syndromes are associated with mitochondrial dysfunction; this book focuses upon diseases linked to these ubiquitous organelles. Accumulation of mitochondrial DNA damage results in mitochondrial dysfunction through two main pathways. Mutation in mitochondrial DNA causes diseases such as Kearns-Sayre syndrome and Pearson syndrome. Mutation in chromosomal DNA causes diseases such as Parkinson's disease and schizophrenia. These and many other diseases are reviewed in this book.




Key Features







  • Presents the detailed structure of mitochondria, mitochondrial function, roles of oxidants and antioxidants in mitochondrial dysfunction.







  • Includes summary of both causes and effects of these diseases.







  • Discusses current and potential future therapies for mitochondrial dysfunction diseases







  • Explores a wide variety of diseases caused by dysfunctional mitochondria.


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Specificații

ISBN-13: 9781032178004
ISBN-10: 1032178000
Pagini: 504
Ilustrații: 33 Illustrations, color; 51 Illustrations, black and white
Dimensiuni: 210 x 280 x 27 mm
Greutate: 1.12 kg
Ediția:1
Editura: CRC Press
Colecția CRC Press

Notă biografică

Shamim I. Ahmad earned his


Master’s degree in Botany from


Patna University, Bihar, India, and


his PhD in Molecular Genetics


from Leicester University, England.


He then joined Nottingham


Polytechnic as a grade 1 lecturer and subsequently was


promoted to the post of Senior Lecturer. Ahmad now


spends much of his time producing/writing medical


books. For more than three decades he researched different


areas of molecular biology/genetics including thymineless


death in bacteria, genetic control of nucleotide


catabolism, development of anti-AIDs drug, control of


microbial infection of burns, phages of thermophilic bacteria,


and microbial flora of Chernobyl after the nuclear


power station accident. But his main interest is DNA


damage and repair specifically by near-ultraviolet light


mostly through the photolysis of biological compounds,


production of reactive oxygen species, and their implications


on human health including skin cancer. He also


investigates near-ultraviolet photolysis of non-biological


compounds such as 8-metoxypsoralen, mitomycin C, and


their importance in psoriasis treatment and in Fanconi


anemia. He has collaborated with the University of


Osaka, Japan, and he and his colleagues were able to


show that a number of naturally occurring enzymes were


able to scavenge the reactive oxygen species.


In 2003 he received a prestigious Asian Jewel Award


in Britain for Excellence in Education. His long time ambition


to produce medical books started in 2007 and since


then he has published Molecular mechanisms of Fanconi


Anemia, Molecular Mechanisms of Xeroderma Pigmentosum;


Molecular Mechanisms of Cockayne Syndrome;


Molecular Mechanisms of Ataxia Telangiectasia; Diseases


of DNA repair; Neurodegenerative diseases; Diabetes: an


Old Disease a New Insight, Obesity: a Practical Guide,


Thyroid: Basic Science and Clinical Practice, and Ultraviolet


light in Human Health, diseases and environment; also


as a co-author the book on Diabetes: A comprehensive


Treatise for patients and Caregivers. His most recent books


are Reactive Oxygen Species in Biology and Human Health


and Aging: Exploring a Complex Phenomenon.


 

Recenzii

"This book presents a compilation of the current knowledge associated with
mitochondrial dysfunction. Although titled as a handbook, it represents a
textbook that covers multiple aspects of the role of mitochondria in human
disease. It is an extensive and detailed review of the biological importance of
mitochondria." - Luis F Escobar, MD., MS., Peyton Manning Children's Hospital


Descriere

Mitochondria produce the chemical energy necessary for eukaryotic cell functions; hence mitochondria are an essential component of health, playing roles in both disease and aging. More than 80 human diseases and syndromes are associated with mitochondrial dysfunction; this book focuses upon diseases linked to mitochondria.