The book presents a comprehensive guide to the study of Lie systems from the fundamentals of differential geometry to the development of contemporary research topics. It embraces several basic topics on differential geometry and the study of geometric structures while developing known applications in the theory of Lie systems. The book also includes a brief exploration of the applications of Lie systems to superequations, discrete systems, and partial differential equations.Offering a complete overview from the topic's foundations to the present, this book is an ideal resource for Physics and Mathematics students, doctoral students and researchers.