This document provides guidance for conducting risk assessments of federal informational systems and organizations, amplifying the guidance in Special Publication 800-39. This document provides guidance for carrying out each of the steps in the risk assessment process (i.e., preparing for the assessment, conducting the assessment, communicating the results of the assessment, and maintaining the assessment) and how risk assessments and other organizational risk management processes complement and inform each other. It also provides guidance to organizations on identifying specific risk factors to monitor on an ongoing basis, so that organizations can determine whether risks have increased to unacceptable levels (i.e., exceeding organizational risk tolerance) and different courses of action should be taken.