Current Federal Regulations (23 CFR 630 Subpart J) encourage States to collect and analyze both safety and mobility data to support the initiation and enhancement of agency-level processes and procedures addressing work zone impacts. The purpose of this guidance document is to provide practitioners with the skills to identify current data sources (both existing data and data collected specifically for the work zone) for use in work zone performance measurement, as well as potential data sources that could be useful to work zone performance measurement in the near future. This document is also intended to assist practitioners in determining how to select and compute useful work zone performance measures, given the data sources available to them. For both current and potential data sources, guidance is presented on the viability of each source for work zone performance measurement, as well as on possibly leveraging opportunities to maximize the value of data collection and extraction efforts. In addition to information about data sources and opportunities, guidance is provided regarding work zone performance measures that the various data sources can support. Where appropriate, examples are provided as to how data assessment, collection, application, and interpretation can be accomplished. In this way, document users can obtain an overall perspective.