Glutamate is purported to be the most important transmitter for normal brain function. Nearly all excitatory neurons in the central nervous system are glutamatergic, and it is estimated that over half of all brain synapses release this agent. In this book, the authors present current research in the study of the functions, regulation and disorders related to glutamate. Topics include glutamate-scavenging in the treatment of acute brain insults; the physiology of glutamate receptors in schizophrenia; how glutamate works as a neurotransmitter and the role of supraspinal GABA and glutamate in the mediation of pain.