Gene and Cell Therapy: Therapeutic Mechanisms and Strategies
Editat de Graca Almeida-Porada, Anthony Atalaen Limba Engleză Hardback – 21 sep 2026
Divided into three sections, the book covers:
• Delivery systems and therapeutic strategies
• Other therapeutic strategies, including technologies that knock down gene expression
• Gene expression, regulation, and detection
• Gene and cell therapies, disease targets, clinical trials, and regulatory issues
Accessible to a broad audience, including students, scientists, physicians, and lay people, this book provides readers with up-to-date, interdisciplinary knowledge and tools to tackle the evolving areas of gene therapy, cell therapy, and tissue engineering. From introductory information to novel technologies and concepts, the book helps readers understand vector design and construction, delivery systems, therapeutic strategies, gene expression and detection, disease targets, clinical applications and trials, cell-based therapies, novel imaging systems, gene regulation, and regulatory affairs.
Preț: 1603.02 lei
Preț vechi: 2161.39 lei
-26% Precomandă
Puncte Express: 2405
Carte nepublicată încă
Livrare prin curier în România Precomanda se expediază când titlul devine disponibil.
Transport gratuit pentru acest produs Plată online sau ramburs, în funcție de opțiunile comenzii.
Retur gratuit în 14 zile Comandă securizată și suport în română.
Doresc să fiu notificat când acest titlu va fi disponibil:
Se trimite...
Specificații
ISBN-13: 9780367771799
ISBN-10: 0367771799
Pagini: 496
Ilustrații: 168
Dimensiuni: 210 x 280 mm
Greutate: 0.45 kg
Ediția:5. Auflage
Editura: CRC Press
Colecția CRC Press
ISBN-10: 0367771799
Pagini: 496
Ilustrații: 168
Dimensiuni: 210 x 280 mm
Greutate: 0.45 kg
Ediția:5. Auflage
Editura: CRC Press
Colecția CRC Press
Public țintă
Postgraduate and ProfessionalCuprins
About the Editors
List of Contributors
Preface
Section I Gene Therapy
1. Biology and Immunology of Recombinant Adeno-Associated Viral Vectors in Gene Therapy
2. Alphavirus Vectors in Gene Therapy and Neuroscience
3. Gene Electrotransfer
4. Evolution of Polyplexes: Refining Structural Motifs Required for Nucleic Acid Delivery
5. Therapeutic Applications of Morpholino Oligonucleotides
6. Nonviral Genome Modification Strategies for Gene Therapy: Transposon, Integrase, and Nuclease Systems
7. Complex In Vitro Models and Their Application in Gene Editing Technologies
8. Gene Therapy for Vision Disorders
Section II Cell Therapies
9. Therapies with Adipose Tissue-Derived Stem/Stromal Cells
10. Placenta-Derived Stem Cells and Their Therapeutic Applications
11. Cell-Based Therapies from Umbilical Cord Blood
12. Cell Therapies for the Treatment of Hepatic Inborn Metabolic Errors
13. Cell Therapies for Gastrointestinal Diseases
14. Cell Therapies for Genitourinary Disorders
15. Translating Stem Cell-Derived Extracellular Vesicle Therapy for Brain Disorders
Section III Cell and Gene Therapy
16. CARtalysts of Change: CAR T Cells at the Intersection of Engineering and Clinical Practice
17. Prenatal Cell and Gene Therapy for Genetic Disorders
18. Cell and Gene Therapies for Cardiovascular Disease
19. Monitoring Gene and Cell Therapies in Living Subjects with Molecular Imaging Technologies
Index
List of Contributors
Preface
Section I Gene Therapy
1. Biology and Immunology of Recombinant Adeno-Associated Viral Vectors in Gene Therapy
2. Alphavirus Vectors in Gene Therapy and Neuroscience
3. Gene Electrotransfer
4. Evolution of Polyplexes: Refining Structural Motifs Required for Nucleic Acid Delivery
5. Therapeutic Applications of Morpholino Oligonucleotides
6. Nonviral Genome Modification Strategies for Gene Therapy: Transposon, Integrase, and Nuclease Systems
7. Complex In Vitro Models and Their Application in Gene Editing Technologies
8. Gene Therapy for Vision Disorders
Section II Cell Therapies
9. Therapies with Adipose Tissue-Derived Stem/Stromal Cells
10. Placenta-Derived Stem Cells and Their Therapeutic Applications
11. Cell-Based Therapies from Umbilical Cord Blood
12. Cell Therapies for the Treatment of Hepatic Inborn Metabolic Errors
13. Cell Therapies for Gastrointestinal Diseases
14. Cell Therapies for Genitourinary Disorders
15. Translating Stem Cell-Derived Extracellular Vesicle Therapy for Brain Disorders
Section III Cell and Gene Therapy
16. CARtalysts of Change: CAR T Cells at the Intersection of Engineering and Clinical Practice
17. Prenatal Cell and Gene Therapy for Genetic Disorders
18. Cell and Gene Therapies for Cardiovascular Disease
19. Monitoring Gene and Cell Therapies in Living Subjects with Molecular Imaging Technologies
Index
Notă biografică
Dr Graça Almeida-Porada earned her MD and her PhD from the School of Medicine and Biomedical Sciences at the University of Porto, Portugal. She is currently a professor and the Director of the Fetal Research and Therapy Program at the Wake Forest Institute for Regenerative Medicine. She is also a professor in the Department of Internal Medicine, Section of Hematology and Oncology, and School of Biomedical Engineering and Sciences, Wake Forest School of Medicine. Dr Almeida-Porada’s research focuses on the development of cellular and gene delivery platforms to treat genetic and immune-mediated diseases. She is particularly interested in improving the outcome of stem cell transplantation and gene therapy in fetal and neonatal patients with genetic disorders, and in developing therapies for children with immunemediated diseases. She is the co-founder of the International Fetal Transplantation and Immunology Society, whose mission is to accelerate clinical applications of stem cell transplantation and gene therapy approaches to treat fetuses with congenital disorders. Dr Almeida-Porada serves on numerous review panels, study sections, and professional and scientific committees, and she is a reviewer for many peer-reviewed journals. She has been a member of several NIH study sections, and she serves as an editor, or on the editorial boards, of multiple scientific journals and book series. Dr Almeida-Porada also serves on the scientific advisory boards for several ongoing prenatal clinical trials, both in the US and in Europe. Dr Almeida-Porada holds several patents, and she has authored more than 300 scientific works including papers, abstracts, and book chapters.
Dr Anthony Atala is a practicing surgeon and the G. Link Professor and Director of the Wake Forest Institute for Regenerative Medicine. His work focuses on bioprinting and growing human cells, tissues, and organs. Seventeen applications of technologies developed in Dr Atala’s laboratory have been used clinically. Dr Atala was elected to the National Academy of Medicine, the National Academy of Inventors, and the American Institute for Medical and Biological Engineering. He is a recipient of the US Congress funded Christopher Columbus Foundation Award, bestowed on a living American who is currently working on a discovery that will significantly affect society, the World Technology Award in Health and Medicine, the Edison Science/Medical Award, the R&D Innovator of the Year Award, and the Smithsonian Ingenuity Award. Dr Atala’s work was listed twice as Time Magazine’s top 10 medical breakthroughs of the year, as one of five discoveries that will change the future of organ transplants and was ranked by the Project Management Institute as one of the top 10 most impactful biotech projects from the past 50 years. Dr Atala was named by Scientific American as one of the world’s most influential people in biotechnology, by U.S. News & World Report as one of 14 Pioneers of Medical Progress in the 21st Century, by Life Sciences Intellectual Property Review as one of 50 key influencers in the life sciences intellectual property arena, and by the journal Nature Biotechnology as one of the top 10 translational researchers in the world. Dr. Atala has led or served several national professional and government committees, including the National Institutes of Health working group on Cells and Developmental Biology, the National Institutes of Health Bioengineering Consortium, and the National Cancer Institute’s Advisory Board. He was a founder of the Tissue Engineering Society, the Regenerative Medicine Society, the Regenerative Medicine Foundation, the Alliance for Regenerative Medicine, the Regenerative Medicine Development Organization, the Regenerative Medicine Manufacturing Society, and the Regenerative Medicine Manufacturing Consortium. Dr Atala is editor of 25 books and 2 journals, has published more than 900 journal articles, and has applied for or received over 300 national and international patents.
Dr Anthony Atala is a practicing surgeon and the G. Link Professor and Director of the Wake Forest Institute for Regenerative Medicine. His work focuses on bioprinting and growing human cells, tissues, and organs. Seventeen applications of technologies developed in Dr Atala’s laboratory have been used clinically. Dr Atala was elected to the National Academy of Medicine, the National Academy of Inventors, and the American Institute for Medical and Biological Engineering. He is a recipient of the US Congress funded Christopher Columbus Foundation Award, bestowed on a living American who is currently working on a discovery that will significantly affect society, the World Technology Award in Health and Medicine, the Edison Science/Medical Award, the R&D Innovator of the Year Award, and the Smithsonian Ingenuity Award. Dr Atala’s work was listed twice as Time Magazine’s top 10 medical breakthroughs of the year, as one of five discoveries that will change the future of organ transplants and was ranked by the Project Management Institute as one of the top 10 most impactful biotech projects from the past 50 years. Dr Atala was named by Scientific American as one of the world’s most influential people in biotechnology, by U.S. News & World Report as one of 14 Pioneers of Medical Progress in the 21st Century, by Life Sciences Intellectual Property Review as one of 50 key influencers in the life sciences intellectual property arena, and by the journal Nature Biotechnology as one of the top 10 translational researchers in the world. Dr. Atala has led or served several national professional and government committees, including the National Institutes of Health working group on Cells and Developmental Biology, the National Institutes of Health Bioengineering Consortium, and the National Cancer Institute’s Advisory Board. He was a founder of the Tissue Engineering Society, the Regenerative Medicine Society, the Regenerative Medicine Foundation, the Alliance for Regenerative Medicine, the Regenerative Medicine Development Organization, the Regenerative Medicine Manufacturing Society, and the Regenerative Medicine Manufacturing Consortium. Dr Atala is editor of 25 books and 2 journals, has published more than 900 journal articles, and has applied for or received over 300 national and international patents.
Descriere
This book presents extensive background and basic information, state-of-the-art technologies, important achievements, and lingering challenges in the fields of gene and cell therapies. This edition also offers more material on the contributors’ research efforts, current technologies, disease targets, and clinical applications.