As access to ARVs becomes assured, the world needs to place equal effort in ensuring that every ART patient receives adequate adherence support. The authors of this book report on the experiences from successful treatment programs in three countries in sub-Saharan Africa at the forefront of the rollout of ARVs. The voices of the patients, their families, community members, and the health workers who care for them have been reported faithfully. They speak of the impact of ART on their daily lives and of the key challenges involved in sustaining the necessary high level of adherence to treatment. Their real life experience is valid and needs to be considered by health program managers who are planning the expansion of ARV treatment programs.