London, 1945 and as the end of the war is declared and the troops start returning home, the nurses of the East End are joining in the celebrations.
For Nurse Connie Byrne the end of the war signals the beginning of a new chapter and as the revelries go on around the city, Connie's mind is on another celebration that she'll be able to arrange - the wedding to her sweetheart, Charlie, set to take place as soon as he arrives home. But when Connie meets Charlie off the train at London Bridge, she finds that his homecoming isn't quite going to go according to plan...
Connie's busy professional life, and the larger-than-life patients in the district, offer a welcome distraction, but for how long? If nursing in the East End has taught Connie anything, it's that life is full of surprises...