The COVID-19 pandemic has affected the lives of many people around the globe and has brought to the fore discussions about the ways in which relations of power have shaped human biology and the health of populations. Focusing on these biopolitics, this collection brings together a number of historical and cultural perspectives on processes of othering in the long transnational human history of epidemics and pandemics. Contributors explore the intertwinement of biopolitics and othering with regard to specific bodies, people, and places, in relation to COVID-19 and beyond, as they discuss othering dynamics in the context of post/colonialism and with reference to a number of different cultural, political, medical and media discourses.