Cantitate/Preț
Produs
Total produse
Vezi coșul
Endocrine Disruptors, Brain, and Behavior de Heather B. Patisaul

Endocrine Disruptors, Brain, and Behavior: Oxford Series in Behavioral Neuroendocrinology

Autor Heather B. Patisaul, Scott M. Belcher
en Limba Engleză Hardback – iun 2017

În domeniul endocrinologiei comportamentale, Endocrine Disruptors, Brain, and Behavior reprezintă o sinteză clinică și teoretică esențială asupra modului în care poluanții chimici interacționează cu axa hormonală pentru a influența sănătatea neuronală. Remarcăm abordarea autorilor Heather B. Patisaul și Scott M. Belcher, care depășesc simpla inventariere a riscurilor, oferind o perspectivă istorică și critică asupra ipotezelor majore care guvernează acest domeniu controversat. Putem afirma că volumul se distinge prin rigoarea cu care tratează relația cauzală dintre expunerea la perturbatori endocrini (EDC) și creșterea prevalenței tulburărilor neurologice, subliniind unde se termină certitudinea datelor și unde încep lacunele de cercetare.

Structura lucrării, publicată sub egida Oxford University Press, facilitează înțelegerea mecanismelor prin care aceste substanțe afectează diferențele sexuale și comportamentul, integrând date din neurobiologie și biologie evoluționistă. Clinicienii care folosesc Endocrine Disruptors and the Developing Brain de Andrea C. Gore ca referință vor găsi aici o completare necesară privind politicile publice și cadrul de reglementare, oferind o viziune mai largă asupra modului în care definițiile administrative ale „efectelor adverse” modelează siguranța chimică la nivel global. Față de abordările farmacologice clasice regăsite în Endocrine-Disrupting Chemicals de Laura Vandenberg, acest volum pune un accent sporit pe tehnologiile emergente de screening și pe nevoia unei abordări interdisciplinare pentru a proteja sănătatea mintală a generațiilor viitoare.

Citește tot Restrânge

Din seria Oxford Series in Behavioral Neuroendocrinology

Preț: 58388 lei

Preț vechi: 84192 lei
-31%

Puncte Express: 876

Carte tipărită la comandă

Livrare economică 11-16 iunie

 Adaugă în coș

Wish list
Gift list
Am citit!
Adaugă în listă

Specificații

ISBN-13: 9780199935734
ISBN-10: 0199935734
Pagini: 270
Ilustrații: 39
Dimensiuni: 155 x 236 x 18 mm
Greutate: 0.5 kg
Editura: Oxford University Press
Colecția OUP USA
Seria Oxford Series in Behavioral Neuroendocrinology

Locul publicării:New York, United States

De ce să citești această carte

Această lucrare este indispensabilă pentru endocrinologi, neurologi și cercetători interesați de sănătatea publică. Cititorul câștigă o înțelegere profundă a modului în care mediul chimic modern ne modelează creierul și comportamentul. Este un argument științific solid pentru actualizarea protocoalelor de testare a siguranței substanțelor, oferind instrumentele necesare pentru a naviga între controversele academice și reglementările legislative actuale.

Despre autor

Heather B. Patisaul și Scott M. Belcher sunt cercetători de renume internațional, specializați în studiul efectelor toxinelor de mediu asupra sistemului neuroendocrin. Heather Patisaul este recunoscută pentru studiile sale privind modul în care expunerea timpurie la perturbatori endocrini, precum bisfenolul A (BPA), influențează dezvoltarea creierului și comportamentele specifice sexului. Scott Belcher contribuie cu o expertiză vastă în mecanismele moleculare ale acțiunii hormonale și toxicologie, activitatea sa fiind esențială pentru înțelegerea riscurilor pe care substanțele chimice industriale le prezintă pentru sănătatea umană.

Descriere

Our world and bodies are becoming increasingly polluted with chemicals capable of interfering with our hormones and thus, possibly, our present and future neural and mental health. As authors Heather Patisaul and Scott Belcher outline, there is a large lack of data and evidence in this causal relationship, which begs a need for further study to accelerate progress in the endocrinology and neuroendocrinology fields.Endocrine Disruptors, Brain, and Behavior focuses on if and how these chemicals, known as endocrine disrupting compounds (EDCs), affect the development and function of the brain and might be contributing to neural disorders rapidly rising in prevalence. The book provides an overall synthesis of the EDC field, including its historical roots, major hypotheses, key findings, and research gaps. The authors explain why even the concept of endocrine disruption is controversial in some circles, how differing definitions of endocrine disruption and what constitutes an "adverse" outcome on the brain shape public policy, and where the current capacity by different stakeholders (industry, academia, regulatory agencies) to evaluate chemicals for safety in a regulatory context begins and ends. The book concludes with suggestions for future research needs and a summary of emerging technology which might prove capable of more effectively evaluating existing and emerging chemicals for endocrine disrupting properties. As such, it provides the context for interdisciplinary and innovative input from a broad spectrum of fields, including those well-schooled in neuroscience, evolutionary biology, brain, behavior, sex differences, and neuroendocrinology.

Recenzii

“Endocrine Disruptors, Brain, and Behavior is a MUST READ for basic scientists and their trainees in the fields of endocrinology and neuroendocrinology-as well as for others who want to understand the issues of 'EDCs.' Two world-class scientists-Heather Patisaul and Scott Belcher, both with national and international experience in the area-bring this very complex topic to the reader in an entirely understandable way. . . . The authors have done a remarkable job separating the science from the politics-and this is no easy task on this subject. I am deeply grateful for this scholarly and readable treatment!”-Thomas Zoeller, PhD, Professor of Biology, University of Massachusetts Amherst
“Patisaul and Belcher eloquently depict how the competing desires for a safer, healthier world and 'better living through chemistry' have woven threads of science and policy into a messy tapestry with many scientific holes to be filled and regulatory knots to be untangled. Their descriptions of the complex behaviors of cells, laboratory animals, and humans make it clear that the endocrine system, particularly as it functions through the brain, is critical to optimizing both.>
“With Endocrine Disruptors, Brain, and Behavior two renowned scientists clarify the complexities of how environmental chemicals act on our children's brains. But going beyond the understandable disquiet they emphasize that increasing knowledge can empower us to find solutions and new ways forward. An important book.”-Barbara Demeneix, PhD, Professor and Head of Department, Comparative Physiology Laboratory, Natural History Museum, Paris and author of Toxic Cocktail: How Chemical Pollution Is Poisoning Our Brains (OUP 2017)

Notă biografică

Heather B. Patisaul, PhD, is a Professor of Biological Sciences at North Carolina State University. She has participated on several national and international expert panels and workshops related to health effects associated with EDCs, including the 2010 World Health Organization Expert Panel on the health risks of Bisphenol A, and the 2012 Workshop on Low Dose Effects of Endocrine Active Chemicals co-organized by the US National Institute for Environmental Health Sciences/NIH and the Joint Research Centre's Institute for Health and Consumer Protection. She was the chair of the 2016 Gordon Conference on Environmental Endocrine Disruptors and a member of the National Research Council Committee on Incorporating 21st Century Science Into Risk-Based Evaluations.Scott M. Belcher, PhD, is a Professor of Biological Sciences at North Carolina State University. He has served on numerous national and international expert panels and workshops related to health effects of EDCs, including being Chair of the 2007 In vitro Mechanism Focus Group at the Chapel Hill Expert panel on BPA's Risk to Human Health; Lead Discussant for the US EPA-FIFRA Scientific Advisory Panel of Endocrine Disruptor Screening Program Tier-1 Battery; and member of the 2010 World Health Organization Expert Panel on the health risks of Bisphenol A. In 2015 he was a presenting member at the European Commission's LIFE EDESIA Workshop on The Role of in vitro Functional Assays for the Assessment of Endocrine Disruption.