Drug Design: Cutting Edge Approaches: Special Publication, cartea 279
Autor Royal Society of Chemistry Editat de Darren R. Floweren Limba Engleză Hardback – 30 sep 2002
Pharmaceutical research draws on increasingly complex techniques to solve the challenges of drug design. Bringing together a number of the latest informatics techniques, this book looks at modelling and bioinformatic strategies; structural genomics and X-ray crystallography; virtual screening; lead optimisation; ADME profiling and vaccine design. A number of relevant case studies, focussing on techniques that have demonstrated their use, will concentrate on G-protein coupled receptors as potential disease targets. Providing details of state-of-the-art research, Drug Design: Cutting Edge Approaches will be invaluable to all drug discovery scientists, including medicinal and combinatorial chemists, molecular modellers, bio- and chemoinformaticians, and pharmacologists, amongst others. University and pharmaceutical company libraries will also benefit from having a copy on their shelves.
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Specificații
ISBN-13: 9780854048168
ISBN-10: 0854048162
Pagini: 202
Ilustrații: 1
Dimensiuni: 156 x 234 x 13 mm
Greutate: 0.46 kg
Ediția:2., Erw. U. Ver
Editura: Royal Society Of Chemistry
Seria Special Publication
ISBN-10: 0854048162
Pagini: 202
Ilustrații: 1
Dimensiuni: 156 x 234 x 13 mm
Greutate: 0.46 kg
Ediția:2., Erw. U. Ver
Editura: Royal Society Of Chemistry
Seria Special Publication
Cuprins
Introduction; High-Throughput X-Ray Crystallography for Drug Discovery; Bioinformatics in Drug Design: a GPCR case study; Virtual Screening of Virtual Libraries - an Efficient Strategy for Lead Generation; Virtual Techniques for Lead Optimisation; The Impact of Physical Organic Chemistry on the Control of Drug-like Properties; Mutagenesis and Modelling Highlight the Critical Nature of the TM2-loop-TM3 region of biogenic amine GPCRS; Computational Vaccine Design; Subject Index.
Descriere
Providing details of state-of-the-art research, Drug Design: Cutting Edge Approaches will be invaluable to all drug discovery scientists.