DNA-Encoded Libraries
Editat de Moreno Wichert, Raphael Franzinien Limba Engleză Hardback – 22 oct 2026
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Specificații
Notă biografică
Raphael M. Franzini, PhD, is a faculty member in the Department of Medicinal Chemistry at the University of Utah. After completing his PhD in Organic Chemistry at Stanford University and postdoctoral research at ETH Zurich, he established his research program focused on DNA-encoded libraries for drug discovery and bioorthogonal chemistry.
Moreno Wichert, PhD, is Principal Scientist of the DNA-Encoded Library Technology platform at Roche Innovation Center Basel, where he oversees all aspects of the technology and supports portfolio projects across disease and therapeutic areas. He completed his PhD at ETH Zurich in DNA-encoded self-assembling chemical library technology for de novo ligand discovery and tumor targeting applications.
Moreno Wichert, PhD, is Principal Scientist of the DNA-Encoded Library Technology platform at Roche Innovation Center Basel, where he oversees all aspects of the technology and supports portfolio projects across disease and therapeutic areas. He completed his PhD at ETH Zurich in DNA-encoded self-assembling chemical library technology for de novo ligand discovery and tumor targeting applications.
Cuprins
List of Contributors
Preface
List of Abbreviations
Part I Principles of DELs
Chapter 1 The Dawn of DNA-Encoded Libraries
Chapter 2 The Architecture of DNA-Encoded Chemical Libraries: From Encoding Schemes to Display Geometry
Chapter 3 Aspects of Chemical Diversity in DNA-encoded Library Designs
Chapter 4 Toolbox for Synthesizing DNA-Encoded Chemical Libraries
Chapter 5 Selection Protocols for DNA-Encoded Libraries
Chapter 6 Informatics and DNA-Encoded Libraries: A Critical Symbiosis for Data Analysis and Workflow Acceleration
Chapter 7 Methods and Art of Hit Prioritization and Validation in DNA-Encoded Libraries
Chapter 8 DNA-Encoded Libraries and Machine Learning
Part II Applications of DELs
Chapter 9 Best Practices in DEL Hit Optimization
Chapter 10 Success Stories of DEL-Derived Hits
Chapter 11 DNA-Encoded Libraries for the Discovery of RNA-Targeting Drugs
Chapter 12 DNA-Encoded Library Selections on the Cell Surface and Inside Live Cells
Chapter 13 Enabling Molecular Glue Degraders and Proximity-Based Drugs with DNA-Encoded Chemical Libraries
Preface
List of Abbreviations
Part I Principles of DELs
Chapter 1 The Dawn of DNA-Encoded Libraries
Chapter 2 The Architecture of DNA-Encoded Chemical Libraries: From Encoding Schemes to Display Geometry
Chapter 3 Aspects of Chemical Diversity in DNA-encoded Library Designs
Chapter 4 Toolbox for Synthesizing DNA-Encoded Chemical Libraries
Chapter 5 Selection Protocols for DNA-Encoded Libraries
Chapter 6 Informatics and DNA-Encoded Libraries: A Critical Symbiosis for Data Analysis and Workflow Acceleration
Chapter 7 Methods and Art of Hit Prioritization and Validation in DNA-Encoded Libraries
Chapter 8 DNA-Encoded Libraries and Machine Learning
Part II Applications of DELs
Chapter 9 Best Practices in DEL Hit Optimization
Chapter 10 Success Stories of DEL-Derived Hits
Chapter 11 DNA-Encoded Libraries for the Discovery of RNA-Targeting Drugs
Chapter 12 DNA-Encoded Library Selections on the Cell Surface and Inside Live Cells
Chapter 13 Enabling Molecular Glue Degraders and Proximity-Based Drugs with DNA-Encoded Chemical Libraries