Although the non steroidal anti-inflammatory agent diclofenac is an old drug, there is ongoing research interest on potential novel indications of the drug, on adverse drug reactions of diclofenac and on the management of these adverse drug reactions. This book aims to contribute knowledge on novel aspects of the pharmacology of diclofenac. Thus, the book provides evidence on three fields: (i) potential novel indications of diclofenac, especially in oncology, (ii) adverse events of diclofenac and (iii) modulation of gastrointestinal and cardiovascular toxicity of diclofenac. The book is focused on the above areas, contributing evidence on: the anticancer effects of diclofenac; the modulation of stress response by diclofenac; rare severe adverse reactions of diclofenac; thyroid effects of diclofenac; maternal and foetal adverse reactions of diclofenac and the modulation of gastrointestinal; the modulation of cardiovascular toxicity of diclofenac. All the chapters are well-written and structured and appropriately referenced. The authors present their own research work and at the same time they provide a well-informed literature review. The book will be interesting for researchers with interest in diclofenac, academic teachers, medical doctors, pharmacologists, pharmacists, and medical students.