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Diagnostic Pathology: Cytopathology: Diagnostic Pathology

Autor Michael J. Thrall, Savitri Krishnamurthy, Yimin Ge
en Limba Engleză Hardback – 19 noi 2026
This expert volume in the Diagnostic Pathology series is an excellent point-of-care resource for practitioners at all levels of experience and training. Covering all aspects of cytology, including gynecologic, nongynecologic exfoliative, fine-needle aspiration, and imaging, it incorporates the most recent clinical, pathologic, and molecular knowledge in the field to provide a comprehensive overview of all key issues relevant to today’s practice. Succinctly written, richly illustrated, and easy to use, Diagnostic Pathology: Cytopathology, fourth edition, is a one-stop reference for accurate, complete pathology reports-ideal as a day-to-day reference or as a reliable training resource.
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Specificații

ISBN-13: 9780443434334
ISBN-10: 0443434336
Pagini: 850
Ilustrații: Approx. 3,290 (approx. 3,290 in full color)
Dimensiuni: 216 x 276 mm
Ediția:4
Editura: Elsevier
Seria Diagnostic Pathology


Cuprins

SECTION 1: GYNECOLOGIC CYTOPATHOLOGY
OVERVIEW
Pap Test and Cervical Cancer Screening: History and Reporting Terminology
Cytopreparation, Instrumentation, and Automated Screening in Gynecologic Cytology
Specimen Adequacy in Cervicovaginal Cytology

BENIGN AND INFECTIOUS CONDITIONS
Normal Pap Test
Infectious and Other Organisms in Pap Tests
Nonneoplastic Findings, Mimics, and Artifacts

SQUAMOUS CELL ABNORMALITIES AND MIMICS
Low-Grade Squamous Intraepithelial Lesion and Mimics
High-Grade Squamous Intraepithelial Lesion and Mimics
Atypical Squamous Cells of Undetermined Significance
Atypical Squamous Cells, Cannot Rule Out High-Grade Squamous Intraepithelial Lesion
Squamous Cell Carcinoma of Cervix

GLANDULAR CELL ABNORMALITIES
Endocervical Adenocarcinoma In Situ, Variants and Mimics
Endocervical HPV-Dependent Invasive Adenocarcinoma
Endocervical HPV-Independent Gastric Type Adenocarcinoma
Endometrial Cancers in Pap Tests
Atypical Glandular Cells: Endocervicals, Endometrials, and Glandulars, NOS
Endometrial Cells in Pap Test and Glandular Cells Status Post Hysterectomy

EXTRAUTERINE CARCINOMAS AND OTHER MALIGNANCIES OF FEMALE GENITAL TRACT
Extrauterine Cancers in Pap Tests
Neuroendocrine Carcinoma of Cervix
Other Uncommon Malignancies in Pap Tests

MOLECULAR TESTING IN GYNECOLOGIC CYTOLOGY
HPV and Other Molecular Testing in Gynecologic Cytology

DIRECTLY SAMPLED ENDOMETRIAL CYTOLOGY
Directly Sampled Endometrial Cytology

ANAL CYTOLOGY
Anal Cytology

SECTION 2: EXFOLIATIVE CYTOPATHOLOGY
GASTROINTESTINAL TRACT
Specimen Types in Respiratory Cytology and Adequacy Criteria
Parasitic Infections
Viral Infections
Esophagitis and Barrett Esophagus
Esophageal Adenocarcinoma
Esophageal Squamous Cell Carcinoma
Gastritis and Intestinal Metaplasia
Gastric Adenocarcinoma
Gastric Lymphoma
Glomus Tumor
Ampulla/Bile Duct/Pancreatic Duct Reactive Changes
Ampulla/Bile Duct/Pancreatic Duct Adenocarcinoma
Colorectal Adenoma/Carcinoma
Neuroendocrine Tumor/Carcinoma
Spindle Cell Neoplasms of Gastrointestinal Tract, Including Gastrointestinal Stromal Tumors

CEREBROSPINAL FLUID
Normal Cerebrospinal Fluid and Contamination by Normal Elements
Infectious Meningitis
Aseptic and Mollaret Meningitis
Subarachnoid Hemorrhage
Neurodegenerative Diseases
Primary Brain Tumors
Leukemia and Lymphoma
Metastasis in Cerebrospinal Fluid

PLEURAL, PERITONEAL, PERICARDIAL, AND PELVIC FLUID AND WASHINGS
Normal Cellular Components, Reactive Mesothelial Proliferations, and Reporting Terminology
Infectious Conditions
Autoimmune Diseases
Mesothelioma in Effusions and Fine Needle Cytology
Malignant Effusion, Carcinomas
Metastatic Sarcomas in Effusions and Washings
Lymphoid Effusions and Secondary Involvement by Hematopoietic Neoplasms
Primary Effusion Lymphoma
Endometriosis and Endosalpingiosis
Ovarian Neoplasms
Immunocytochemistry, Histochemistry, and Other Ancillary Techniques

URINARY CYTOLOGY
Normal Urinary Cytology, Specimen Types, and Reporting Terminology
Ileal Conduit Specimens
Noninfectious Benign Conditions
Infectious Benign Conditions
Reactive Urothelial Changes
Low-Grade Urothelial Lesions
Atypical Urothelial Cells
High-Grade Urothelial Cancer
Squamous Cell Carcinoma of Urinary Bladder
Adenocarcinoma of Urinary Bladder
Other Malignancies in Urinary Cytology
Renal Pelvic Cytology
Ancillary Testing, UroVysion, and Others

SECTION 3: FINE-NEEDLE ASPIRATION, SUPERFICIAL
OVERVIEW
Superficial Aspiration Technique

THYROID GLAND
Ultrasound-Guided Thyroid Fine-Needle Aspiration
Thyroid Fine-Needle Aspiration Reporting Terminology and Specimen Adequacy
Thyroid Follicular Nodular Disease
Chronic Lymphocytic/Hashimoto Thyroiditis
Granulomatous Thyroiditis
Graves Disease/Diffuse Toxic Goiter
Pigmented Thyroid Lesions and Crystals
Atypia of Undetermined Significance/Follicular Lesion of Undetermined Significance
Follicular Neoplasm/Suspicious for a Follicular Neoplasm
Oncocytic Follicular Neoplasm in Thyroid Fine-Needle Aspiration
Papillary Thyroid Carcinoma, Classic Subtype
Papillary Thyroid Carcinoma Subtypes
Medullary Thyroid Carcinoma
Poorly Differentiated Thyroid Carcinoma
Anaplastic Thyroid Carcinoma
Thyroid Lymphoma
Metastatic Carcinoma to Thyroid
Other Thyroid and Perithyroidal Lesions Encountered in Fine-Needle Aspiration

PARATHYROID GLAND
Parathyroid Cyst, Adenoma, and Carcinoma

LYMPH NODES

Overview
Lymph Node Aspiration: Indications, Techniques, and Reporting
FNA Sample Prep and Triage in Evaluating Suspected Lymphoma

Benign, Infectious, and Reactive Hyperplasia
Inflammatory and Reactive Lymphoid Hyperplasia
Granulomatous Lymphadenitis, Infectious and Sarcoid
Rosai-Dorfman Disease

Metastatic Malignancies
HPV-Mediated Carcinomas in Neck Lymph Nodes
Metastatic Melanoma
Other Metastatic Malignancies Encountered in
Lymph Node Fine-Needle Aspiration

Nodal B-Cell Lymphoma
Small Lymphocytic Lymphoma
Lymphoplasmacytic Lymphoma
Mantle Cell Lymphoma
Nodal Marginal Zone Lymphoma
Follicular Lymphoma
Burkitt Lymphoma
Large B-Cell Lymphoma

Extranodal B-Cell Lymphoma
Plasmacytoma
Mediastinal Large B-Cell Lymphoma
Plasmablastic Lymphoma

T-Cell Lymphoma
Peripheral T-Cell Lymphoma
Mycosis Fungoides
Angioimmunoblastic Lymphoma
ALK(+) Anaplastic Large Cell Lymphoma
T-Cell Lymphoblastic Lymphoma

Hodgkin Lymphoma
Nodular Lymphocyte-Predominant Hodgkin Lymphoma
Classic Hodgkin Lymphoma

EYE
Approach to Ophthalmic Cytology
Infections in Ophthalmic Cytopathology
Neoplasms in Ophthalmic Cytopathology

SALIVARY GLAND

Overview
Approach to Interpretation of Salivary Gland
Aspiration Biopsies and Reporting Terminology (Milan System)

Benign Lesions
Normal Salivary Gland and Sialadenitis on Aspiration
Cysts
Pleomorphic Adenoma
Warthin Tumor
Myoepithelioma
Salivary Gland Oncocytoma

Malignant Neoplasms
Adenoid Cystic Carcinoma
Acinic Cell Carcinoma
Mucoepidermoid Carcinoma
Basaloid Neoplasms, Benign and Malignant
Carcinoma Ex Pleomorphic Adenoma
Adenocarcinoma, NOS
Polymorphous Adenocarcinoma
Salivary Duct Carcinoma
Salivary Gland Secretory Carcinoma
Myoepithelial Carcinoma
Cribriform Adenocarcinoma
Metastatic Carcinoma
Primary and Metastatic Nonepithelial Tumors

BREAST

Overview
Role of Fine-Needle Aspiration of Breast, Techniques and Triple Test

Benign Breast Lesions
Inflammatory and Granulomatous Conditions
Fat Necrosis
Nonproliferative and Proliferative Changes in Breast
Radial Scar/Complex Sclerosing Lesion
Gynecomastia
Mucocele-Like Lesion

Benign Neoplasms
Fibroadenoma
Granular Cell Tumor of Breast
Papillary Neoplasms
Myofibroblastoma, Mammary

Malignant Neoplasms
Ductal Carcinoma and Variants of Invasive Mammary Carcinoma
Lobular Carcinoma
Phyllodes Tumor
Angiosarcoma and Other Sarcomas
Lymphomas and Metastatic Tumors

Nipple Discharge
Cytology Specimens for Risk Assessment of Breast Cancer

SKIN AND SUBCUTANEOUS CYTOLOGY
Cutaneous and Adnexal Cytology
Fat Pad Aspiration for Amyloid

SECTION 4: FINE-NEEDLE ASPIRATION, DEEP ORGANS AND TISSUES OVERVIEW
Techniques and Modalities of Deep Aspiration Biopsies
Techniques and Modalities of Bronchoscopic Aspiration and Small Biopsies
Techniques and Modalities of Gastrointestinal Endoscopic Aspiration and Small Biopsies

RESPIRATORY TRACT, INCLUDING LUNG FNAS
Specimen Types in Respiratory Cytology and Adequacy Criteria
Benign and Reactive Changes
Fungal Yeasts and Hyphal Organisms
Pneumocystis Pneumonia
Parasitic Organisms
Viral Infections (Cytomegalovirus, Herpesvirus, and Others)
Mycobacteria and Other Bacterial Infections
Sarcoidosis and Other Immune-Related Conditions
Pulmonary Alveolar Proteinosis and Mimics
Miscellaneous Findings, Including Contaminants
Adenocarcinoma of Lung
Squamous Cell Carcinoma of Lung
Small Cell Carcinoma of Lung
Large Cell Neuroendocrine Carcinoma of Lung
Carcinoid and Atypical Carcinoid of Lung
Rare Benign and Low Malignant Potential Tumors
Rare Malignant Tumors
NUT Carcinoma
SMARCA4-Deficient Undifferentiated Tumor
Pulmonary Lymphoma
Pulmonary Metastasis

MEDIASTINUM

Overview
Anatomic Compartments and Constituent Tumors

Nonneoplastic Lesions
Mediastinal Cysts and Inflammatory Lesions

Neoplasms
Thymoma
Thymic Carcinoma
Germ Cell Tumors
Mediastinal Neurogenic Tumors
Metastatic Tumors of Mediastinum

LIVER

Overview
Cytology of Normal Liver
Inflammatory and Infectious Conditions of Liver

Benign Hepatic Neoplasms
Hepatocellular Adenoma
Focal Nodular Hyperplasia
Hemangioma and Other Vascular Tumors of Liver

Malignant Neoplasms
Hepatocellular Carcinoma
Hepatoblastoma
Liver Metastasis

KIDNEY

Overview
Cytology of Normal Kidney

Indolent Neoplasms and Benign Lesions
Renal Cysts
Angiomyolipoma
Renal Oncocytoma and Other Indolent Oncocytic Tumors
Metanephric Adenoma
Metanephric Stromal Tumor
Xanthogranulomatous Pyelonephritis/Malakoplakia

Malignant Neoplasms
Clear Cell Renal Cell Carcinoma
Papillary Renal Cell Carcinoma
Clear Cell Papillary Renal Cell Tumor
Chromophobe Renal Cell Carcinoma
TFE3- and TFEB-Rearranged Renal Cell Carcinomas
Collecting Duct Carcinoma
Renal Medullary Carcinoma
Mucinous Tubular and Spindle Cell Carcinoma of Kidney
Renal Neuroendocrine Tumor
Primary Renal Sarcomas in Adults
Renal Lymphomas
Nephroblastoma (Wilms Tumor)
Clear Cell Sarcoma of Kidney
Congenital Mesoblastic Nephroma
Rhabdoid Tumor of Kidney
Metastatic Tumors to Kidney
Other Rare and Recently Described Malignant Kidney Tumors

Tumors Of Renal Pelvis
Urothelial Carcinoma

ADRENAL GLAND

Overview

Cytology of Normal Adrenal Gland

Adrenal Cortical Lesions
Adrenal Cortical Adenoma
Adrenal Cortical Carcinoma
Metastatic Tumors to Adrenal Gland

ADRENAL MEDULLARY LESIONS
Pheochromocytoma

PANCREAS

Overview
Cytology of Normal Pancreas
Pancreaticobiliary Cytology Reporting Terminology, Cyst Evaluation

Nonneoplastic Lesions
Pancreatitis
Lymphoepithelial Cyst of Pancreas
Intra- and Peripancreatic Splenules

Neoplasms
Serous Microcystic Adenoma
Mucinous Cystic Neoplasm
Intraductal Papillary Mucinous Neoplasm
Solid Pseudopapillary Neoplasm
Pancreatic Neuroendocrine Tumor
Pancreatic Ductal Adenocarcinoma
Unusual Variants of Ductal Carcinoma
Acinar Cell Carcinoma
Lymphoma and Secondary Tumors of Pancreas

BONE

Overview
Approach to Cytologic/Small Biopsy Diagnosis of
Primary Bone Tumors

Neoplasms
Chondromas of Bone and Soft Tissue
Chondroblastoma
Giant Cell Tumor
Osteoblastoma
Adamantinoma
Langerhans Cell Histiocytosis
Chordoma
Osteosarcoma
Chondrosarcoma
Ewing Sarcoma
Bone Lymphoma
Metastatic Tumors of Bone

SOFT TISSUE

Overview
Approach to Cytologic/Small Biopsy Diagnosis of Primary Soft Tissue Lesions

Adipocytic Tumors
Benign Adipose Tissue Tumors
Liposarcoma

Fibroblastic/Myofibroblastic Lesions
Fibrosarcoma
Myofibroblastoma
Low-Grade Myofibroblastic Sarcoma
Low-Grade Fibromyxoid Sarcoma
Myxofibrosarcoma

Tumors of Muscle Origin
Smooth Muscle Tumors
Skeletal Muscle Tumors

Vascular and Pericytic Tumors
Hemangioma, Soft Tissue
Epithelioid Hemangioendothelioma
Kaposi Sarcoma
Angiosarcoma

Other Tumors
Undifferentiated Pleomorphic Sarcoma
Giant Cell Tumor of Tendon Sheath
Other Reactive and Neoplastic Soft Tissue Entities
Mesenchymal Chondrosarcoma
Solitary Fibrous Tumor
Intramuscular Myxoma
Synovial Sarcoma
Epithelioid Sarcoma
Alveolar Soft Part Sarcoma
Clear Cell Sarcoma of Soft Tissue
Desmoplastic Small Round Cell Tumor

NEUROPATHOLOGY
Neuropathology Squash Preparations, Infectious
Neuropathology Squash Preparations, Glial Neoplasms
Neuropathology Squash Preparations, Nonglial Neoplasms

SECTION 5: MANAGEMENT AND ANCILLARY TESTING
CYTOPREPARATORY AND QUALITY MANAGEMENT
Cytopreparatory Techniques and Instrumentation in
Nongynecologic Cytology
Quality Improvement and Laboratory Management for Cytopathology

ANCILLARY TESTING
Immunocytochemistry
Molecular Techniques