Cyber-physical systems closely combine and coordinate subsystems consisting of both computational and physical elements. Such systems have become indispensable in the fields of aerospace, automotive and the automation industries, as well as in consumer appliances. Safety, security and reliability are all essential elements of the trustworthiness of these modern cyber-physical systems. Protecting the data within such systems from external attack security and protecting the environment from any potential malfunction or misuse of these systems safety are subjects traditionally considered separately, but a closer