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Deciphering Cancer Resistance: Mechanisms, Targets, and Emerging Therapies: Novel approaches to overcome cancer resistance to conventional therapies

Editat de Abraham Pedroza, Rosa M. Alvarez-Gomez
en Limba Engleză Paperback – aug 2026
Deciphering Cancer Resistance: Mechanisms, Targets, and Emerging Therapies addresses the critical challenge of treatment resistance in oncology. The book provides a comprehensive examination of the cellular, molecular, and genetic mechanisms behind resistance, unveiling insights from cancer biology and genomics that inform novel therapeutic strategies. Sections explore cutting-edge technologies like CAR-T cell therapy, nanotechnology, and artificial intelligence, highlighting their role in discovering new treatment modalities. Readers will find the latest preclinical and clinical data, including newly FDA-approved therapies, demonstrating their potential to improve patient outcomes.

For academics, this resource consolidates the latest research and clinical developments, aiding researchers, clinicians, and students in staying updated on advancements. It will also be a great guide for graduate studies and research, offering critical insights into drug development and targeted therapies for professionals in the pharmaceutical and biotechnology sectors, ultimately driving progress in cancer treatment.

  • Provides an in-depth analysis of cellular, molecular, and genetic mechanisms behind cancer treatment resistance
  • Explores cutting-edge technologies such as CAR-T cell therapy, nanotechnology, and artificial intelligence in addressing resistance
  • Presents the latest preclinical and clinical data, including newly FDA-approved therapies, to enhance patient outcomes
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Specificații

ISBN-13: 9780443456596
ISBN-10: 0443456593
Pagini: 330
Dimensiuni: 191 x 235 mm
Editura: ELSEVIER SCIENCE
Seria Novel approaches to overcome cancer resistance to conventional therapies


Cuprins

Part I: Molecular and Cellular Mechanisms Underlying Cancer Resistance (Chapters 1-5)
1. Molecular Pathways in Cancer Resistance: A Comprehensive Overview
2. Role of Tumor Microenvironment in Therapy Resistance
3. Epigenetic Modifications and Drug Resistance in Cancer
4. Cancer Stem Cells as Drivers of Resistance to Conventional Therapies
5. Mechanisms of Immune Escape and Resistance to Immunotherapy in Cancer Treatment

Part II: Emerging Therapeutic Approaches to Overcome Resistance (Chapters 6-13)
6. Targeting Epigenetic Regulators: Promising Avenues
7. CRISPR and Gene Editing in Combating Drug Resistance
8. Synthetic Lethality and PARP Inhibitors in Resistant Tumors
9. Role of Nanomedicine in Delivering Targeted Therapies
10. Overcoming Resistance to Immunotherapy with Checkpoint Blockade
11. Exploiting Tumor Metabolism to Reverse Resistance
12. The Role of MicroRNAs and Non-coding RNAs in Therapeutic Resistance
13. Overcoming Cancer Resistance: The Role of Emerging CAR-T Cell Approaches

Part III: Clinical Applications and Future Perspectives (Chapters 14-18)
14. Biomarker Development for Predicting Therapy Resistance
15. Precision Medicine in the Context of Cancer Resistance
16. Combination Therapies to Enhance Treatment Efficacy in Resistant Cancers
17. AI-Driven Approaches to Overcoming Cancer Resistance
18. Future Directions in Overcoming Cancer Resistance: Challenges and Opportunities