When Isabelle wakes up naked and alone in her hotel room, the entire world turns upside down as the doomsday clock is turned to a minute from midnight. Surrounded by a city filled with horrific mutations of the towns former citizens; Isabelle, Lucas, and the orphaned police canine, Fayth struggle to escape the city, hoping there is still time to stop the impending apocalypse. All the while wondering if their own actions played a part in the tragedy unfolding before them.