Cyanobacteria Biotechnology: Advanced Biotechnology
Autor P Hudsonen Limba Engleză Hardback – 4 mai 2021
Lucrarea Cyanobacteria Biotechnology aduce o abordare integrată, unind rigoarea cercetării biologice fundamentale cu viziunea pragmatică a ingineriei biotehnologice. Față de literatura existentă, care adesea separă studiul fiziologic de aplicațiile comerciale, acest volum oferă un ghid sistematic asupra metabolismului cianobacteriilor privit ca un „modul” ce poate fi optimizat pentru producția industrială. Descoperim aici nu doar mecanismele teoretice, ci și cerințele logistice și experiențele concrete din mediul de afaceri, elemente esențiale pentru tranziția de la laborator la scară industrială.
Comparabil cu Synthetic Biology of Cyanobacteria de Weiwen Zhang în ceea ce privește rigoarea științifică, volumul editat de P Hudson se distinge prin accentul pus pe experiența industrială reală și pe crearea unui cadru de lucru (framework) pentru proiectarea proceselor. În timp ce alte titluri din domeniu se concentrează strict pe instrumente de bioinformatică sau protocoale de laborator, Cyanobacteria Biotechnology analizează critic limitările și oportunitățile economice ale utilizării acestor microorganisme fotosintetice.
Structura narativă a textului urmează o logică clară: de la principiile de bază ale metabolismului, la tehnicile actuale de inginerie metabolică și, în final, la studiile de caz din industrie. Ritmul este cel al unui manual avansat, dens în date tehnice, dar orientat spre soluții aplicabile. Considerăm că includerea acestui titlu în seria Advanced Biotechnology subliniază relevanța sa pentru curriculumul academic modern și pentru cercetătorii care urmăresc dezvoltarea de tehnologii verzi sustenabile.
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Specificații
ISBN-13: 9783527347148
ISBN-10: 3527347143
Pagini: 560
Dimensiuni: 176 x 248 x 32 mm
Greutate: 1.22 kg
Ediția:1
Editura: Wiley Vch
Seria Advanced Biotechnology
Locul publicării:Weinheim, Germany
ISBN-10: 3527347143
Pagini: 560
Dimensiuni: 176 x 248 x 32 mm
Greutate: 1.22 kg
Ediția:1
Editura: Wiley Vch
Seria Advanced Biotechnology
Locul publicării:Weinheim, Germany
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De ce să citești această carte
Recomandăm această carte biotehnologilor și microbiologilor care doresc să depășească faza de cercetare fundamentală. Cititorul câștigă o înțelegere profundă a modului în care metabolismul cianobacteriilor poate fi manipulat pentru aplicații industriale. Este o resursă esențială deoarece oferă atât fundamentul teoretic, cât și experiența practică necesară pentru a proiecta procese biotehnologice eficiente și scalabile.
Descriere scurtă
Guides the reader through the interesting and useful aspects of cyanobacteria metabolism but will keep true to a biotechnology vision.
Cuprins
1 Inorganic carbon assimilation in cyanobacteria: mechanisms, regulation and engineering
1.1 Introduction - the need for a carbon-concentrating mechanism
1.2 The carbon-concentrating mechanism (CCM) among cyanobacteria
1.3 Regulation of Ci assimilation
1.4 Engineering the cyanobacterial CCM
1.5 Photorespiration
1.6 Concluding remarks
2 Electron transport inc yanobacteria and its potential in bioproduction
2.1. Introduction
2.2. Electron transport in a bioenergetic membrane
2.3. Respiratory electron transport
2.4 The role of electron sinks in photoprotection
2.5 Regulating electron flux into different pathways
2.6 Spatial organisation of electron transport complexes
2.7 Manipulating electron transport for synthetic biology applications
2.8 Future challenges in cyanobacterial electron transport
3 Optimizing the spectral fit between cyanobacteria and solar radiation in the light of sustainability applications
3.1 Introduction
3.2 The molecular basis and efficiency of Oxygenic Photosynthesis
3.3 Fit between the spectrum of solar radiation and the action spectrum of photosynthesis
3.4 Expansion of the PAR region of Oxygenic Photosynthesis
3.5 Modulation and optimization of the transparency of photobioreactors
3.6 Full control of the light regime: LEDs inside the PBR
3.7 Conclusions and prospects
4 What we can learn from measuring metabolic fluxes in cyanobacteria
4.1 Central carbon metabolism in cyanobacteria: an overview and renewed pathway knowledge
4.2 Methodologies for predicting and quantifying metabolic fluxes in cyanobacteria
4.3 Cyanobacteria fluxome in response to altered nutrient modes and environmental conditions
4.4 Metabolic fluxes redirected in cyanobacteria for biomanufacturing purposes
4.5 Synopsis and future directions
5 Synthetic biology in cyanobacteria and applications for biotechnology
5.1 Getting genes into cyanobacteria
5.2 Basic synthetic control of gene expression in cyanobacteria
5.3 Exotic signals for controlling expression
5.4 Advanced regulation: the near future
5.5 Conclusions
6 Sink Engineering in Photosynthetic Microbes
6.1 Introduction
6.2 Source and Sink
6.3 Regulation of Sink Energy in Plants
6.4 Engineered pathways as sinks in Photosynthetic Microbes
6.5 What are key source/sink regulatory hubs in photosynthetic microbes?
6.6 Concluding Remarks
7 Design principles for engineering metabolic pathways in cyanobacteria
7.1 Introduction
7.2 Cofactor optimization
7.3 Incorporation of thermodynamic driving force into metabolic pathway design
7.4 Development of synthetic pathways for carbon conserving photorespiration and enhanced carbon fixation
7.5 Summary and future perspective on cyanobacterial metabolic engineering
8 Engineering cyanobacteria for efficient photosynthetic production: ethanol case study
8.1 Introduction
8.2 Pathway for ethanol synthesis in cyanobacteria
8.3 Selection of optimal cyanobacteria ?chassis,? strain for ethanol production
8.4 Metabolic engineering strategies toward more efficient and stable ethanol production
8.5 Exploring the response in cyanobacteria to ethanol
8.6 Metabolic engineering strategies to facilitate robust cultivation against biocontaminants
8.7 Conclusions and Perspectives
9 Engineering cyanobacteria as host organisms for production of terpenes and terpenoids
9.1 Terpenoids and industrial applications
9.2 Terpenoid biosynthesis in cyanobacteria
9.3 Natural occurrence and physiological roles of terpenes and terpenoids in cyanobacteria
9.4 Engineering cyanobacteria for terpenoid production
9.5 Summary and outlook
10 Cyanobacterial biopolymers
10.1 Polyhydroxybutryate
10.2. Cyanophycin granules in cyanobacteria
11 Biosynthesis of fatty acid derivatives by cyanobacteria: from basics to biofuel production
11.1 Introduction
11.2 Overview of fatty acid metabolism
11.3 Basic technologies for production of free fatty acids
11.4 Advanced technologies for enhancement of free fatty acid production
11.5 Hydrocarbon production in cyanobacteria
11.6 Advanced technologies for enhancement of hydrocarbon production
11.7 Basic technologies for production of fatty alcohols
11.8 Advanced technologies for enhancement of fatty alcohol production
11.9 Basic technologies for production of fatty acid alkyl esters
11.10 Perspectives
12 Product export in cyanobacteria
12.1 Introduction
12.2 Secretion mediated by membrane-embedded systems
12.3. Membrane vesicle-mediated secretion
12.4 Concluding remarks
13 Harnessing Solar-Powered Oxic N2-fixing Cyanobacteria for the BioNitrogen Economy
13.1 Introduction
13.2 Physiology and Implications of Oxic Nitrogen Fixation
13.3 Major Biotechnology Applications for Diazotrophic Cyanobacteria
13.4 Conclusions
14 Traits of fast-growing cyanobacteria
14.1 Introduction
14.2 Why is growth rate significant?
14.3 An overview of factors affecting growth rates of cyanobacteria
14.4 An overview of the fast-growing model cyanobacteria
14.5 Relationship between light usage and growth rate in model strains
14.6 Molecular determinants of fast growth of S. elongatus UTEX 2973
14.7 Carbon fluxes in fast-growing strains determined using metabolic flux analysis (MFA)
14.8 Engineering cyanobacteria for fast growth
14.9 Conclusion
15 Cyanobacterial biofilms in natural and synthetic environments
15.1 Motivation
15.2 Introduction to biofilms: biology and applications
15.3 Cyanobacteria in natural biofilms and microbial mats
15.4 Introduction to (Photo-)biotechnology
15.5 Benefits of microscale systems for (photo-)biofilm cultivation
15.6 Oxygen accumulation and its impacts
15.7 Resource management in biofilms
15.8 Applications of photosynthetic biofilms
15.9 Outlook
16 Growth of Photosynthetic Microorganisms in Different Photobioreactors Operated Outdoors
16.1 Background
16.2 Case studies of Outdoor Cultivations of Photosynthetic Microorganisms
6.3 Conclusion
Descriere
Unites a biological and a biotechnological perspective on cyanobacteria, and includes the industrial aspects and applications of cyanobacteria Cyanobacteria Biotechnology offers a guide to the interesting and useful features of cyanobacteria metabolism that keeps true to a biotechnology vision. In one volume the book brings together both biology and biotechnology to illuminate the core acpects and principles of cyanobacteria metabolism. Designed to offer a practical approach to the metabolic engineering of cyanobacteria, the book contains relevant examples of how this metabolic "module" is currently being engineered and how it could be engineered in the future. The author includes information on the requirements and real-world experiences of the industrial applications of cyanobacteria. This important book: Brings together biology and biotechnology in order to gain insight into the industrial relevant topic of cyanobacteria Introduces the key aspects of the metabolism of cyanobacteria Presents a grounded, practical approach to the metabolic engineering of cyanobacteria Offers an analysis of the requirements and experiences for industrial cyanobacteria Provides a framework for readers to design their own processes Written for biotechnologists, microbiologists, biologists, biochemists, Cyanobacteria Biotechnology provides a systematic and clear volume that brings together the biological and biotechnological perspective on cyanobacteria.