Since its inception, one of the distinguishing features of the project of European integration has been the overcoming of internal borders. This aim has had one of the most remarkable outcomes in the history of cross-border cooperation, resulting in the creation of territorial structures known as Euroregions, with or without legal personality, and with substantial financial support from EU institutions. This distinctive element is characteristic of the models and achievements of cross-border cooperation in Europe and North America. At a time of reflection about the European integration model and its future, it is interesting to investigate the different aspects involved in cross-border cooperation, from a historical perspective projected onto the future. This volume looks at cross-border cooperation from a multiplicity of perspectives, examining its motivations, its actors, its inclusion in the context of international relations, its organizational models, its outcomes and its impact on labour markets, economic development, neighbourhood policies and the creation of new identities. These issues are analysed within a number of different European geographical locations, assessing how far we have come and exploring the road that still lies ahead.