Creatinine, a muscle waste product, is widely interpreted as a measure of renal function. However, the serum level reflects not only renal excretion, but also the generation, intake, and metabolism of creatinine. In this book, the authors present current research in the study of the production, diagnostic uses and role in renal disease of creatinine. Topics include the diagnostic use of creatinine in pre-eclampsia; serum creatinine and its effect and management in renal and hepatic disease; evaluation of renal function in patients with cirrhosis; the role of creatinine in kidney disease in neonates, infants and children; and retinol X creatinine in kidney disease.