A military experiment gone horribly wrong has spread a virus that will change our world forever. Loving parents are now transforming into flesh eating beasts and attacking their own children. Thirteen year old Kyle, his twin brother Craig and sister Lauren manage to escape the carnage and flee north but find that the monsters are not their only predators. Struggling to survive in the forests of upstate New York they face unimaginable horrors as they try in vain to reach the safety of their father's cabin. Years pass and Kyle, now seventeen and only months from turning, has lost everything. On the verge of giving up he meets an immune adult who gives him new hope. They trek to Manhattan to search for a cure and find that an answer may lie in a lab in Philadelphia. Fighting against all odds to get there, they encounter bandits bent on sacrificing the young and engage in a fierce battle between man and beast. But they can't stop; they must find a cure, before they are consumed with rage.