Bioinformatics is an inter-disciplinary field which is concerned with the development of new methods for understanding large and complex biological data structures. It combines the principles of biology, mathematics, computer science, statistics and information engineering for the analysis of biological molecules such as DNA and RNA. A computational model is a complex non-linear model which requires extensive resources to study a system using computer simulation. Bioinformatics makes use of computational modeling systems to study DNA sequencing, genome annotation, genomics and mutation. It also finds applications in the field of gene expression, protein expression and analysis of cellular organization. The book studies, analyses and upholds the pillars of bioinformatics and computational modeling, and its utmost significance in modern times. The various studies that are constantly contributing towards advancing technologies and evolution of this field are examined in detail. This book attempts to assist those with a goal of delving into this field.