The experimental teaching of materials science and engineering (MSE) is important because the comprehensive applications and the practical knowledge of the professionals are not only an important way for undergraduate students to grasp the knowledge but also to understand the purpose of the study. In order to cultivate students' ability to solve complex engineering problems, more comprehensive experiments should be designed. Besides the essential basic experiments in the first few chapters, most of the experiments designed in this book are comprehensive, hence the title. This book breaks the boundaries in the experimental courses of MSE. The experiments in this book are modularized into five parts, including preliminary exploration of materials science and engineering, fundamentals of chemistry and crystallography, material properties, material preparation and treatment, and material applications. Besides the experiments, the appendices will describe the most relevant aspects of experimental safety, error, and data presentation in a general way. The contents and requirements of the experimental report are suggested. At the end of each chapter, a list of books, journal articles, and websites is provided for extended reading on the topics covered in the chapter. This book covers the main contents of experimental courses of MSE. The experiments cover the forefront of scientific research and the materials industry with appropriate modification. It intends to serve as a textbook for undergraduate students and aims to help teachers find a wide enough variety of experiments to construct in an experimental course.