Comparative Fish Immunology, Volume 42 in the Fish Physiology series, presents chapters written by leading experts. Covering a broad range of topics, this edition explores the evolution and function of immune systems in fish, with particular attention to both innate and adaptive immune mechanisms across diverse aquatic species. Chapters examine adaptive immunity in jawless vertebrates and the unique VLR system, the role of antimicrobial peptides in teleost infections, and the use of zebrafish as a model for studying innate immune responses. Additional contributions explore pharyngeal mucosal lymphoid structures, the evolutionary origins of germinal centers in fish, and mechanisms of antigen presentation in teleosts.

Other chapters address microbiota–host immune interactions, emerging insights into teleost neuroimmunology, and the modulation of immune function through behavioral fever. Together, these contributions provide a comprehensive overview of current discoveries and evolving perspectives in fish immunology, offering valuable insights for researchers, immunologists, and aquatic biologists interested in the physiology and immune biology of fishes.

• Presents the latest advances in fish immunology, with contributions from leading experts in the field
• Explores both innate and adaptive immune mechanisms across diverse fish species
• Highlights emerging topics such as microbiota–host immune interactions, teleost neuroimmunology, and behavioral fever
• Discusses evolutionary perspectives on immune system development in jawless and teleost fishes
• Serves as an essential reference for researchers, aquatic biologists, and immunologists interested in fish physiology and immune biology