This book provides a framework for integrating complex systems that are problem-centric, human-centered, and provides an interdisciplinary, multi-methodological purview of multiple perspectives surrounding the human factors/human actors within living ecosystems. This book will provide useful theoretical and practical information to human factors, human-computer interaction, cognitive systems engineering personnel who are currently engaged in human-centered design or other applied aspects of modeling, simulation, and design that requires joint understanding of theory and practice.