This book is the second of two volumes devoted to the work of Theo Kuipers, a leading Dutch philosopher of science. Philosophers and scientists from all over the world, thirty seven in all, comment on Kuipers’ philosophy, and each of their commentaries is followed by a reply from Kuipers. The present volume is devoted to Kuipers’ neo-classical philosophy of science, as laid down in his Structures in Science (Kluwer, 2001). Kuipers defends a dialectical interaction between science and philosophy in that he views philosophy of science as a meta-science which formulates cognitive structures that provide heuristic patterns for actual scientific research, including design research. In addition, Kuipers pays considerable attention to the computational approaches to philosophy of science as well as to the ethics of doing research. Thomas Nickles, David Atkinson, Jean-Paul van Bendegem, Maarten Franssen, Anne Ruth Mackor, Arno Wouters, Erik Weber & Helena de Preester, Eric Scerri, Adam Grobler & Andrzej Wisniewski, Alexander van den Bosch, Gerard Vreeswijk, Jaap Kamps, Paul Thagard, Emma Ruttkamp, Robert Causey, Henk Zandvoort comment on these ideas of Kuipers, and many present their own account. The present book also contains a synopsis of Structures in Science. It can be read independently of the first volume of Essays in Debate with Theo Kuipers, which is devoted to Kuipers’ From Instrumentalism to Constructive Realism (2000).