The Affordable Care Act (ACA) has altered the landscape of health care by forcing behavioral health workers from their silos into a rapidly changing, fast-paced, integrative care setting of increased accountability and accessibility. In order to survive in this transition, behavioral health care will have to be transportable beyond traditional one-to-one psychotherapy models, be viewed as a less consumable commodity, and be able to efficiently treat the myriad of comorbid psychological disorders that are present in every area of medicine. Fortunately, cognitive behavioral therapy (CBT) has a long tradition of empirical success with a wide variety of clinical disorders in youth. Accordingly, CBT provides a robust platform from which to launch new clinical models and delivery systems beyond the limitations of a single-disorder paradigm to target transdiagnostic factors that perpetuate psychological disorders in youth. This book begins by briefly reviewing the challenges that clinicians face, working with children in the new health care era. The book then discusses trauma focused CBT for children with developmental disabilities; CBT for informal cancer caregivers; CBT in pain management of adult chronic nonmalignant pain patients; and CBT for rheumatoid arthritis.