The author analyzes and deciphers a number of public health issues from a clinical perspective. Depressive illness is understood as a trans-structural affect rather than a symptom. It is understood as a phenomenon that escapes the unconscious elaboration of a lost subject embodying, with its liquefied body, the reactivation of the object of its original loss. This book offers a rigorous and enlightening reading of mental disorders, explaining the psychic mechanisms at work in each clinical category: psychic disorders produced by the unconscious of a human subject subjected to the power of words, or elementary phenomena beyond meaning arising from the open-air unconscious of a human subject subjected to mental automatisms. It presents a clinical approach to psychic disorders, whether disabling or not, developed in the practice or in the day-to-day work of hospital carers and medical-social support staff, which can be used to improve the tools of care and psychological support for patients with major life difficulties.