Clinical Neuroscience: Psychopathology and the Brain, Second Edition, uses a student-friendly, integrative, and empirically based approach to present the neuroscience underlying various psychological disorders. The text begins with a tour of the brain's fundamental building blocks (neuroanatomy, neurochemistry, neurophysiology, and neurodevelopment) before moving on to such mental health challenges and illnesses as traumatic brain injury, Parkinson's disease, addiction, schizophrenia, obsessive-compulsive disorder, and depression. The final section of the book includes chapters devoted to the maintenance of mental health, including stress and coping, psychoneuroimmunology, and hunger regulation. Pedagogical features including chapter-opening vignettes (Connections), case studies (A Case in Point), running marginal glossaries, and feature boxes (Brain Matters) illuminate the course content for students as they learn about the value of translational research (i.e., transforming basic research into applied therapies). Clinical Neuroscience: Psychopathology and the Brain, Second Edition, emphasizes the value of the scientific method, relevant empirical information, and the practice of utilizing multiple perspectives so that meaningful progress can be made toward the identification of the most effective treatment strategies. Ultimately, all students will have a sound scientific foundation on which to build a greater understanding of the neurobiology inherent in psychological properties and mental health.