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Chronic Hepatitis C Virus: Advances in Treatment, Promise for the Future

Editat de Mitchell L. Shiffman
en Limba Engleză Hardback – 30 noi 2011
Chronic Hepatitis C Virus: Lessons from the Past, Promise for the Future documents the monumental advances that have been made in our understanding of chronic HCV during the past decade. The first section reviews the natural history of chronic HCV, how this virus can affect other organs in addition to the liver, and whether treating chronic HCV alters the natural history of this disease. Section 2 reviews the advances that have been made in the treatment of chronic HCV during the past decade with interferon based therapy. Separate chapters on response guided therapy and how to manage the adverse events associated with these medications provide the physician with the concepts required to more effectively treat chronic HCV now and in the future. As the genetics of virologic response have recently been elucidated, a chapter is devoted to helping the clinician understand how genes that modulate disease processes and their treatment are identified and utilized in clinical care. Section 3 deals with the future of HCV treatment and specific inhibitors of HCV. Specific chapters explain how targets for drugs are identified and how drugs are then developed and tested; how mutations of HCV develop and how anti-viral agents will affect this process; the most up to date data regarding the treatment of chronic HCV with peginterferon, ribavirin and anti-viral agents; and the potential to treat chronic HCV with just oral anti-viral agents and without peginterferon and ribavirin in the future. The final section of this book covers issues related to liver transplantation in patients with chronic HCV. Separate chapters review the natural history of chronic HCV in liver transplant recipients and the impact of utilizing HCV positive donors. The volume concludes with chapters that cover the treatment of chronic HCV both prior to and after liver transplantation with potent anti-viral agents. Chronic Hepatitis C Virus: Lessons from the Past, Promise for the Future is a valuable resource for all physicians caring for patients with chronic HCV.
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Specificații

ISBN-13: 9781461411918
ISBN-10: 1461411912
Pagini: 344
Ilustrații: XVI, 332 p. 53 illus., 33 illus. in color.
Dimensiuni: 178 x 254 x 23 mm
Greutate: 0.82 kg
Ediția:2012
Editura: Springer
Colecția Springer
Locul publicării:New York, NY, United States

Public țintă

Professional/practitioner

Cuprins

Section I: Natural History of Chronic HCV
 
Ch. 1- Epidemiology of Chronic HCV
            Gary Davis
           
Ch. 2- Acute HCV     
            Katja Deterding
            Heiner Wedemeyer
            Michael P. Manns
 
Ch. 3- Assessing the Progression of Chronic HCV to Cirrhosis
            Xavier Forns
 
Ch. 4- Chronic HCV and Steatosis
            Dawn McDowell Torres
            Stephen A. Harrison
 
Ch. 5- Chronic HCV and Hepatocellular Carcinoma
            Morris Sherman
 
Ch. 6- Extrahepatic Manifestations of Chronic HCV
            Antonio Craxi
            Vincenza Calvaruso
 
Ch. 7- Chronic HCV and HIV Co-infection 
            Patrick Ingiliz
            Maud Lemoine
            Yves Benhamou
 
Ch. 8- Chronic HCV in Patients with Renal Disease
            Paul Martin
            Fabrizio Fabrizi
 
Ch. 9- Does Treatment Alter the Natural History of Chronic HCV
            Bruce Bacon
            Fasiha Kanwal
 
Section II: Treatment of Chronic HCV with Interferon Based Therapy
 
Ch. 10- Treatment with Interferon and Ribavirin
            Stuart Roberts
            William Kemp
 
Ch. 11- Immune Modulators and Other Agents
            Edgar D. Charles
            Ira M. Jacobson
 
Ch. 12- Measuring HCV RNA and Assessing Virologic Response
            Jean-Michel Pawlotsky
           
Ch. 13- Response Guided Therapy
            Mitchell Shiffman
 
Ch. 14- Managing the Side Effects of Therapy
            Curtis Cooper
 
Ch. 15- The Genetics of Virologic Response
            Andrew J Muir
            Alison B. Jazwinski
 
Ch. 16- Maintenance Therapy with Peginterferon
            Nezem Afdahl
            Raza Malik
 
 
Section III: Anti-viral Therapy for Chronic HCV
 
Ch. 17- Anti-viral Targets in HCV
            Bernd Kronenberger
            Stefan Zeuzem
 
Ch. 18- Mutations and the Development of Anti-viral Resistance
            Geoffrey Dusheiko
            Anna Maria Geretti
 
Ch. 19- Peginterferon, Ribavirin and Anti-viral Triple Therapy
            Patrick Marcellin
            Nathalie Boyer
            Tarik Asselah
 
Ch. 20- Treating Chronic HCV without Interferon and/or Ribavirin
            Ed Gane
 
Ch. 21- Maintenance Therapy with Oral Anti-viral Agents
            Donald M. Jensen
            Andrew Aronsohn
 
Section IV: Liver Transplantation for Chronic HCV
 
Ch. 22- Natural History of Chronic HCV after Liver Transplantation         
            Michael Charlton
            Bart J. Veldt
 
Ch. 23- Use of HCV Positive Organs in Patients with and without Chronic HCV
            Robert Brown
            Elizabeth C. Verna
 
Ch. 24- Treating HCV Prior to Liver Transplantation
            Greg Everson
            Alvaro Martinez-Camacho
            Brett E. Fortune
 
Ch. 25- Treating HCV after Liver Transplantation
            Sammy Saab
            Michael Chang
            Hubert Sung
           
 
 
Ch. 2- Acute HCV     
            Katja Deterding
            Heiner Wedemeyer
            Michael P. Manns
 
Ch. 3- Assessing the Progression of Chronic HCV to Cirrhosis
            Xavier Forns
 
Ch. 4- Chronic HCV and Steatosis
            Dawn McDowell Torres
            Stephen A. Harrison
 
Ch. 5- Chronic HCV and Hepatocellular Carcinoma
            Morris Sherman
 
Ch. 6- Extrahepatic Manifestations of Chronic HCV
            Antonio Craxi
            Vincenza Calvaruso
 
Ch. 7- Chronic HCV and HIV Co-infection 
            Patrick Ingiliz
            Maud Lemoine
            Yves Benhamou
 
Ch. 8- Chronic HCV in Patients with Renal Disease
            Paul Martin
            Fabrizio Fabrizi
 
Ch. 9- Does Treatment Alter the Natural History of Chronic HCV
            Bruce Bacon
            Fasiha Kanwal
 
Section II: Treatment of Chronic HCV with Interferon Based Therapy
 
Ch. 10- Treatment with Interferon and Ribavirin
            Stuart Roberts
            William Kemp
 
Ch. 11- Immune Modulators and Other Agents
            Edgar D. Charles
            Ira M. Jacobson
 
Ch. 12- Measuring HCV RNA and Assessing Virologic Response
            Jean-Michel Pawlotsky
           
Ch. 13- Response Guided Therapy
            Mitchell Shiffman
 
Ch. 14- Managing the Side Effects of Therapy
            Curtis Cooper
 
Ch. 15- The Genetics of Virologic Response
            Andrew J Muir
            Alison B. Jazwinski
 
Ch. 16- Maintenance Therapy with Peginterferon
            Nezem Afdahl
            Raza Malik
 
 
Section III: Anti-viral Therapy for Chronic HCV
 
Ch. 17- Anti-viral Targets in HCV
            Bernd Kronenberger
            Stefan Zeuzem
 
Ch. 18- Mutations and the Development of Anti-viral Resistance
            Geoffrey Dusheiko
            Anna Maria Geretti
 
Ch. 19- Peginterferon, Ribavirin and Anti-viral Triple Therapy
            Patrick Marcellin
            Nathalie Boyer
            Tarik Asselah
 
Ch. 20- Treating Chronic HCV without Interferon and/or Ribavirin
            Ed Gane
 
Ch. 21- Maintenance Therapy with Oral Anti-viral Agents
            Donald M. Jensen
            Andrew Aronsohn
 
Section IV: Liver Transplantation for Chronic HCV
 
Ch. 22- Natural History of Chronic HCV after Liver Transplantation         
            Michael Charlton
            Bart J. Veldt
 
Ch. 23- Use of HCV Positive Organs in Patients with and without Chronic HCV
            Robert Brown
            Elizabeth C. Verna
 
Ch. 24- Treating HCV Prior to Liver Transplantation
            Greg Everson
            Alvaro Martinez-Camacho
            Brett E. Fortune
 
Ch. 25- Treating HCV after Liver Transplantation
            Sammy Saab
            Michael Chang
            Hubert Sung
           
 
 
Ch. 2- Acute HCV     
            Katja Deterding
            Heiner Wedemeyer
            Michael P. Manns
 
Ch. 3- Assessing the Progression of Chronic HCV to Cirrhosis
            Xavier Forns
 
Ch. 4- Chronic HCV and Steatosis
            Dawn McDowell Torres
            Stephen A. Harrison
 
Ch. 5- Chronic HCV and Hepatocellular Carcinoma
            Morris Sherman
 
Ch. 6- Extrahepatic Manifestations of Chronic HCV
            Antonio Craxi
            Vincenza Calvaruso
 
Ch. 7- Chronic HCV and HIV Co-infection 
            Patrick Ingiliz
            Maud Lemoine
            Yves Benhamou
 
Ch. 8- Chronic HCV in Patients with Renal Disease
            Paul Martin
            Fabrizio Fabrizi
 
Ch. 9- Does Treatment Alter the Natural History of Chronic HCV
            Bruce Bacon
            Fasiha Kanwal
 
Section II: Treatment of Chronic HCV with Interferon Based Therapy
 
Ch. 10- Treatment with Interferon and Ribavirin
            Stuart Roberts
            William Kemp
 
Ch. 11- Immune Modulators and Other Agents
            Edgar D. Charles
            Ira M. Jacobson
 
Ch. 12- Measuring HCV RNA and Assessing Virologic Response
            Jean-Michel Pawlotsky
           
Ch. 13- Response Guided Therapy
            Mitchell Shiffman
 
Ch. 14- Managing the Side Effects of Therapy
            Curtis Cooper
 
Ch. 15- The Genetics of Virologic Response
            Andrew J Muir
            Alison B. Jazwinski
 
Ch. 16- Maintenance Therapy with Peginterferon
            Nezem Afdahl
            Raza Malik
 
 
Section III: Anti-viral Therapy for Chronic HCV
 
Ch. 17- Anti-viral Targets in HCV
            Bernd Kronenberger
            Stefan Zeuzem
 
Ch. 18- Mutations and the Development of Anti-viral Resistance
            Geoffrey Dusheiko
            Anna Maria Geretti
 
Ch. 19- Peginterferon, Ribavirin and Anti-viral Triple Therapy
            Patrick Marcellin
            Nathalie Boyer
            Tarik Asselah
 
Ch. 20- Treating Chronic HCV without Interferon and/or Ribavirin
            Ed Gane
 
Ch. 21- Maintenance Therapy with Oral Anti-viral Agents
            Donald M. Jensen
            Andrew Aronsohn
 
Section IV: Liver Transplantation for Chronic HCV
 
Ch. 22- Natural History of Chronic HCV after Liver Transplantation         
            Michael Charlton
            Bart J. Veldt
 
Ch. 23- Use of HCV Positive Organs in Patients with and without Chronic HCV
            Robert Brown
            Elizabeth C. Verna
 
Ch. 24- Treating HCV Prior to Liver Transplantation
            Greg Everson
            Alvaro Martinez-Camacho
            Brett E. Fortune
 
Ch. 25- Treating HCV after Liver Transplantation
            Sammy Saab
            Michael Chang
            Hubert Sung
           
 
 

Recenzii

From the reviews:
“This book is an important contribution to the field. … This well-written, concise, and current book will find a home on the shelves of many hepatologists and gastroenterologists. In addition, because it is so readable, it should be useful for students, GI/hepatology fellows, and midlevel providers dealing with patients and doing research. … This is a concise, updated, and well-written book that belongs in the libraries of healthcare providers and researchers in the field of HCV infection as well as medical institutions.” (Paul Angulo, Doody’s Review Service, November, 2012)
“Chronic Hepatitis C Virus: Advances in Treatment, Promise for the Future represents a timely new text that is focused on the natural history, treatment, and liver transplantation for chronic hepatitis C virus (HCV) infection. … an excellent background reference for MD and PhD students, trainees, and clinicians in understanding the scientific basis for current management of chronic HCV infection and highlighting key areas for future investigation. … is a welcome addition to any library and true to its name … .” (Richard Sterling and Joseph Lim, Gastroenterology, Vol. 143 (6), 2012)

Notă biografică

Mitchell L.  Shiffman, MD
Liver Institute of Virginia, Bon Secours Health System, Richmond, VA, USA

Textul de pe ultima copertă

Chronic Hepatitis C Virus: Advances in Treatment, Promise for the Future documents the monumental advances that have been made in our understanding of chronic HCV during the past decade. The first section reviews the natural history of chronic HCV, how this virus can affect other organs in addition to the liver, and whether treating chronic HCV alters the natural history of this disease. Section 2 reviews the advances that have been made in the treatment of chronic HCV during the past decade with interferon based therapy. Separate chapters on response guided therapy and how to manage the adverse events associated with these medications provide the physician with the concepts required to more effectively treat chronic HCV now and in the future. As the genetics of virologic response have recently been elucidated, a chapter is devoted to helping the clinician understand how genes that modulate disease processes and their treatment are identified and utilized in clinical care. Section 3 deals with the future of HCV treatment and specific inhibitors of HCV. Specific chapters explain how targets for drugs are identified and how drugs are then developed and tested; how mutations of HCV develop and how anti-viral agents will affect this process; the most up to date data regarding the treatment of chronic HCV with peginterferon, ribavirin and anti-viral agents; and the potential to treat chronic HCV with just oral anti-viral agents and without peginterferon and ribavirin in the future. The final section of this book covers issues related to liver transplantation in patients with chronic HCV. Separate chapters review the natural history of chronic HCV in liver transplant recipients and the impact of utilizing HCV positive donors. The volume concludes with chapters that cover the treatment of chronic HCV both prior to and after liver transplantation with potent anti-viral agents. Chronic Hepatitis C Virus: Advances in Treatment, Promise for the Future is a valuable resource for all physicians caring for patients with chronic HCV.

Caracteristici

New anti-viral therapy explored
Outlines monumental advances in treatment
Presents current and future treatment options
Includes supplementary material: sn.pub/extras