Cholera is a life-threatening diarrhoeal disease that can spread rapidly and in explosive epidemics from one region to another, affecting large numbers of people. V cholerae, a gram-negative motile bacterium, is the causative agent of this intestinal disease. This book presents topical research from across the globe in the study of cholera; its symptoms, diagnosis and treatment. Some topics discussed, herein, include emergence of new virulence factors of vibrio cholera as potential vaccine candidates; possible targets for quorum quenching of vibrio cholerae; the environmental reservoirs and vector of vibrio cholerae; and current African perspectives of cholera.