This document updates and consolidates the guidance provided in the Chemical Stockpile Emergency Preparedness Program (CSEPP) Planning Guidance (2008) and CSEPP Programmatic Guidance (2008) and supersedes these documents. This guidance has also been reorganized into a structure consistent with the CSEPP National Benchmarks. This document provides the basis for Federal, State, and local program managers to implement CSEPP in keeping with the Department of the Army (Army)/Federal Emergency Management Agency (FEMA) CSEPP Strategic Plan. References have been made throughout this document to the following function-specific guidance documents that serve as its technical companions: Annual CSEPP Cooperative Agreement Guidance; CSEPP Exercise Policy and Guidance (December 2012), (aka The Blue Book); CSEPP Medical Resource Guide; CSEPP Public Affairs Compendium Workbook. Chapter 1 provides an overview of the statutory and programmatic history of CSEPP, the organizational roles and responsibilities, and the management structure. Chapter 2 provides a summary of the hazards and risks associated with the U.S. Army chemical weapons stockpile. Chapters 3-14 provide guidance on each of the twelve CSEPP National Benchmarks. They are intended to provide a description of the critical components of each benchmark to assist program managers at the Federal, State, and local level in assigning responsibilities and developing budgets. Appendices A and B provide a summary of the specific hazard and risk associated with the stockpiles at Blue Grass (Kentucky) and Pueblo (Colorado). Appendix C provides a glossary of the terminology that may be unfamiliar and a list of acronyms. Appendix D explains how the Policy Papers that originally guided the program have been incorporated into CSEPP Guidance.