This is the first textbook to explain human aging from genes to clinical disease. With over 4,000 references, it explores both the fundamental processes of aging and the resultant tissue-by-tissue clinical pathology, detailing both breaking research and current state-of-the art clinical interventions in aging and age-related disease. It is the only book on the market to emphasize the theory of aging as caused by cell senescence rather than the traditionally held wear-and-tear theory.