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Cell Biology de Thomas D. Pollard

Cell Biology

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Notă GoodReads:
en Limba Engleză Hardback – 28 Feb 2023

Reader-friendly Cell Biology, 4th Edition, provides a concise but comprehensive foundation for students entering research or health care career paths. Award winning illustrations help readers quickly grasp general principles. The authors have thoroughly updated this popular text to provide readers with the current understanding of the principles of normal cellular function along with examples of how molecular defects predispose to human disease. Major new themes in the 4th edition include the roles of intrinsically disordered polypeptides and phase separation in cellular functions, the influence of new molecular structures on understanding mechanisms, and the impact of exciting new methods¿from single cell RNA sequencing to second generation super resolution fluorescence microscopy¿on advancing our understanding. 

  • Clear, readable explanations provide a concise story about how cells function at the molecular level.    

  • An intuitive chapter flow starts with genome organization, gene expression, and RNA processing as a foundation for understanding every aspect of cellular function and physiology. 

  • Brings cellular biology to life for students interested in medical science by explaining how mutations in genes can compromise virtually every cellular system and predispose to human disease. Knowledge of cell biology has led to new treatments for cancer, heart failure, cystic fibrosis, and many other diseases. 

  • Unique illustrations with realistic proportions and relationships explain every cellular process including the assembly of SARS CoV-2, the structures attaching mitotic chromosomes to microtubules, the mechanism of DNA replication and how pumps, carriers and channels orchestrate physiological processes from synaptic transmission to cellular volume regulation. 

  • Covers exciting breakthroughs such as SMC motor proteins actively organizing chromosomal DNA, TOR kinases regulating metabolism, new types of immunotherapy for cancer treatment, mechanisms regulating fast axonal transport and their relation to neurodegenerative diseases, how completion of DNA replication sets the time for cells to enter mitosis, how a cascade of signals specifies the site of cell division, and newly understood pathways of normal and pathological cell death. 

  • Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices. 

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Specificații

ISBN-13: 9780323758000
ISBN-10: 0323758002
Pagini: 944
Dimensiuni: 216 x 276 mm
Ediția: 4
Editura: Elsevier

Cuprins

  1. Section I Introduction to Cell Biology
  2. 1.Introduction to Cells
  3. 2.Evolution of Life on Earth
  4. Section II Chemical and Physical Background
  5. 3.Molecules: Structures and Dynamics
  6. 4.Biophysical Principles
  7. 5.Macromolecular Assembly
  8. 6.Research Strategies
  9. Section III Chromatin, Chromosomes, and the Cell Nucleus
  10. 7.Chromosome Organization
  11. 8.DNA Packaging in Chromatin and Chromosomes
  12. 9.Nuclear Structure and Dynamics
  13. Section IV Central Dogma: From Gene to Protein
  14. 10.Gene Expression
  15. 11.Eukaryotic RNA Processing
  16. 12.Protein Synthesis and Folding
  17. Section V Membrane Structure and Function
  18. 13.Membrane Structure and Dynamics
  19. 14.Membrane Pumps
  20. 15.Membrane Carriers
  21. 16.Membrane Channels
  22. 17.Membrane Physiology
  23. Section VI Cellular Organelles and Membrane Trafficking
  24. 18.Posttranslational Targeting of Proteins
  25. 19.Mitochondria, Chloroplasts, Peroxisomes
  26. 20.Endoplasmic Reticulum
  27. 21.Secretory Membrane System and Golgi Apparatus
  28. 22.Endocytosis and the Endosomal Membrane System
  29. 23.Processing and Degradation of Cellular Components
  30. Section VII Signaling Mechanisms
  31. 24.Plasma Membrane Receptors
  32. 25.Protein Hardware for Signaling
  33. 26.Second Messengers
  34. 27.Integration of Signals
  35. Section VIII Cellular Adhesion and the Extracellular Matrix 28.Cells of the Extracellular Matrix and Immune System
  36. 29.Extracellular Matrix Molecules
  37. 30.Cellular Adhesion
  38. 31.Intercellular Junctions
  39. 32.Connective Tissues
  40. Section IX Cytoskeleton and Cellular Motility
  41. 33.Actin and Actin-Binding Proteins
  42. 34.Microtubules and Centrosomes
  43. 35.Intermediate Filaments
  44. 36.Motor Proteins
  45. 37.Intracellular Motility
  46. 38.Cellular Motility
  47. 39.Muscles
  48. Section X Cell Cycle
  49. 40.Introduction to the Cell Cycle
  50. 41.G1 Phase and Regulation of Cell Proliferation
  51. 42.S Phase and DNA Replication
  52. 43.G2 Phase, Responses to DNA Damage, and Control of Entry Into Mitosis
  53. 44.Mitosis and Cytokinesis
  54. 45.Meiosis
  55. 46.Programmed Cell Death Appendix
  56. Cell SnapShots

Notă biografică

Thomas Dean Pollard is a prominent educator, cell biologist and biophysicist whose research focuses on understanding cell motility through the study of actin filaments and myosin motors. He is Sterling Professor of Molecular, Cellular & Developmental Biology and a Professor of Cell Biology and Molecular Biophysics & Biochemistry at Yale University. He was Dean of Yale's Graduate School of Arts and Sciences from 2010 to 2014, and President of the Salk Institute for Biological Studies from 1996 to 2001. Pollard is very active in promoting scientific education and research primarily through two major societies, both of which he is a past President: the American Society for Cell Biology and the Biophysical Society