Carbazoles are important aromatic heterocyclic compounds isolated from plants or synthetically obtained. Today, many carbazole derivatives are used in different industrial sectors, especially in the fields of physical chemistry, materials chemistry, and pharmaceuticals. In this Special Issue, "Carbazole derivatives: latest progress and prospects", recent studies on carbazole derivatives that are utilized, such as ¿1-blocking, anticancer (e.g., STAT inhibitors, microtubule-targeting agents), and antidiabetic as well as antiviral (e.g., for the treatment of COVID-19 infection) agents, are reported.