Long before the term alternative was part of our medical culture, Dr. Josef Issels created the world s first fully integrative cancer therapy, curing advanced, recurrent cancer. Issels hypothesized that primary and recurrent malignancies result from a tendency of the body to produce tumors. He therefore made use of every weapon in his arsenal to reduce tumors and strengthen the immune response. In "Cancer: A Second Opinion, "Issels describes the treatment that produced the most remarkable, independently verified cure rate in medical history."