Remembered as the official who failed to keep Luther in the Catholic fold, Tommaso de Vio, Cardinal Cajetan (1469-1534) was a multi-faceted figure whose significance extends beyond those days in Augsburg. In the 1520s, he embarked on a labour of biblical commentary that occupied the final decade of his life, producing over a million words of translation and commentary. Offering an overview of this remarkable body of work, Michael O’Connor argues that Cajetan’s motive was the renewal of Christian living (more ‘Catholic Reform’ than ‘Counter-Reformation’), and that his method was a bold and fresh hybrid of scholasticism and Renaissance humanism, correcting the Vulgate’s errors and expounding the text almost exclusively according to the literal sense.