Proceedings of the 38th Annual Conference on Computer Applications and Quantitative Methods in Archaeology, Granada, Spain, April 2010. This volume contains the proceedings of the 38th Computer Applications and Quantitative Methods in Archaeology (CAA) Conference, held April 6th-9th 2010, in Granada, Spain. The theme of the conference was 'Fusion of Cultures', aiming to reflect both the scope of the conference and the spirit of the host city - a celebrated venue for such disciplinary interplay between archaeologists, computer scientists, and mathematicians.