This manual is for use by doctors, nurses, rehabilitation specialists, National Buruli Ulcer Control Programme managers and other health workers involved in the prevention of disability activities in Buruli ulcer. It provides up-to-date guidelines based on the experience and problems of managing Buruli ulcer in the field as well as the available evidence from other conditions. It will be most helpful if it is used in conjunction with a participatory method of training to develop knowledge and skills.