The Vindiciae, contra tyrannos was the most infamous of the monarchomach treatises produced during the French wars of religion, and continued to be revered (or execrated) as a key part of the radical canon for well over a century after its publication. It is one of the first attempts to advance a systematic justification, with interlocking secular and religious arguments, of resistance against legitimately constituted political authority. This edition presents the first complete and accurate English translation of the work, a comprehensive apparatus, and an introduction which provides the first detailed analysis of the argument and also reconsiders the much-disputed question of authorship. It will be of interest to a wide range of scholars working on the history of political thought and early modern Europe.